@techreport{oai:kindai.repo.nii.ac.jp:02000414,
 author = {赤木, 將男 and AKAGI, Masao},
 note = {40週齢の野生型および高回転型骨粗鬆症を示すつくば高血圧マウス（THM）にDMM手術を行い、膝OAモデルを作成した。脛骨内側軟骨下骨の骨パラメータと形態変化をμCTにて観察し、骨細胞数およびTRAPおよびRANKL陽性細胞数を組織学的に評価した。BV/TVおよびBMDは経時的に低下し、それぞれ術後4週および8週で有意に低下した。しかし、12週でBMD低下を伴うBV/TV増加を認めた。軟骨下骨高さも経時的に減少し、12週で有意に低下した。骨細胞数は経時的に減少し4週で有意差を認めた。TRAPおよびRANKL発現細胞数は経時的に増加し、2週で有意差を認めた。以上の変化はTHMで著しく促進された。, Knee OA was produced by the DMM (destabilization of medial meniscus) surgery for 40-week-old wild type mice and Tsukuba hypertensive mice (THM) with high tourn-over osteoporosis. Changes in bone parameters and shape in the medial tibial subchondral bone (SB) were observed by μCT. Numbers of osteocytes,TRAP positive and RANKL positive cells in the SB were counted histologically. BV/TV and BMD decreased with time after operation, and significant differences were noted after 4 and 8 weeks, respectively. 12 weeks after the DMM surgery, however, an increase in BV/TV with a decrease in BMD was noted. Height of the medial tibial SB decreased with time and a significant decrease was noted after 12 weeks. Number of osteocytes in the SB decreased with time and a significant decrease was noted after 4 weeks. TRAP positive and RANKL positive cells increased with time and significant increases were noted after 2 weeks, respectively. In THM, all these changes above mentioned was enhanced significantly., 研究分野：変形性膝関節症、局所レニン・アンギオテンシン系、人工関節置換術},
 title = {早期変形性関節症の軟骨下骨骨量減少の機序解明：骨細胞アポトーシスとRANKL発現}
}