{"created":"2023-11-15T07:17:45.174371+00:00","id":2000411,"links":{},"metadata":{"_buckets":{"deposit":"3793f022-144a-45bf-adfa-5e12d18e3b84"},"_deposit":{"created_by":42,"id":"2000411","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000411"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000411","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"5","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"大塚, 篤司","creatorNameLang":"ja"},{"creatorName":"Otsuka, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60582054","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"皮膚アレルギー病態における末梢神経の役割が注目されている。シュワン細胞特異的光刺激マウスを作成し、接触皮膚炎モデルで解析したが、炎症の程度に差はなかった。シングルセルRNAシークエンスでシュワン細胞のサブセットを発見し、末梢神経とシュワン細胞が黄色ブドウ球菌による皮膚炎モデルで重要な役割を果たすことを見出した。神経軸索が炎症に寄与している可能性が示唆されるが、シュワン細胞そのものの直接的影響は不明である。今後、シュワン細胞が影響を及ぼす皮膚疾患の可能性を検討する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"The role of peripheral nerves in skin allergy diseases is gaining attention, with a focus on distinguishing nerve fibers and Schwann cells. Schwann cell-specific optogenetic mice were created for basic analysis, but in a contact dermatitis model, inflammation didn't differ from control mice. Single-cell RNA sequencing revealed subsets of Schwann cells in the epidermis. In a Staphylococcus aureus-induced dermatitis model, many eosinophils infiltrated the skin, and RTX treatment revealed the importance of peripheral nerves and Schwann cells. Both produced chemokines, and TLR2 KO mice showed reduced inflammation with eosinophils and basophils being the main inflammatory cells. The direct impact of Schwann cells on skin allergy reactions remains unclear, but nerve fibers' contribution to inflammation is suggested. Future research will explore Schwann cells' potential involvement in skin diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：皮膚アレルギー疾患","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K08689seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000411/files/20K08689seika.pdf"},"version_id":"66c2bb8c-486b-40ab-b961-eb7685580279"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K08689","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08689/"},"subitem_award_titles":[{"subitem_award_title":"皮膚アレルギー疾患におけるシュワン細胞の病態関与","subitem_award_title_language":"ja"},{"subitem_award_title":"Pathological involvement of Schwann cells in cutaneous allergic diseases.","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"接触皮膚炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シュワン細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮膚アレルギー疾患におけるシュワン細胞の病態関与","subitem_title_language":"ja"},{"subitem_title":"Pathological involvement of Schwann cells in cutaneous allergic diseases.","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"皮膚アレルギー疾患におけるシュワン細胞の病態関与","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000411","relation_version_is_last":true,"title":["皮膚アレルギー疾患におけるシュワン細胞の病態関与"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-09T05:16:53.065904+00:00"}