{"created":"2023-11-15T07:17:25.524191+00:00","id":2000406,"links":{},"metadata":{"_buckets":{"deposit":"e58d440a-798e-4dba-ac77-dd6de1f025f0"},"_deposit":{"created_by":42,"id":"2000406","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000406"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000406","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378692288":{"attribute_name":"研究協力者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"コーマイヤー, ジェイコブ","creatorNameLang":"ja"},{"creatorName":"Kohlmeier, Jacob","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トムセン, アラン","creatorNameLang":"ja"},{"creatorName":"Thomsen, Allan","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"84420","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"国立研究開発法人医薬基盤・健康・栄養研究所","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"國澤, 純","creatorNameLang":"ja"},{"creatorName":"Kunisawa, Jun","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"32682","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"明治大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"長竹, 貴広","creatorNameLang":"ja"},{"creatorName":"Nagatake, Takahiro","creatorNameLang":"en"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"8","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"高村, 史記","creatorNameLang":"ja"},{"creatorName":"Takamura, Shiki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90528564","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"肺粘膜に定着する滞在型メモリーCD8 T細胞（CD8 TRM）は様々な株のインフルエンザウイルスに対して感染防御効果を示すが、維持期間が他の組織と比較し短い。本研究では肺CD8 TRM維持のを長期化を目指すべく、その分化・維持機構の解明を目的とした。まず、感染初期には肺マクロファージが局所抗原刺激を供給することでTRM分化を促進していることを突き止めた。また、肺CD8 TRMは飢餓時においてもオートファジー非依存的に維持されることを見出した。また、アデノウイルスベクター経鼻接種にて廃墟奥所に長期抗原提示を誘導すると、循環型メモリーが抗原刺激を受け、TRMへと分化し続けることを突き止めた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Although tissue-resident memory CD8 T cells (CD8 TRMs) in the lung mucosa confer localized protection against challenges with various strains of influenza viruses, their longevity is shorter than that of other tissues. In this study, we aimed to elucidate the differentiation and maintenance mechanisms of pulmonary CD8 TRMs in order to extend their longevity. First, we found that pulmonary macrophages promote TRM differentiation by providing local antigen stimulation in the early stages of infection. We also found that the lung CD8 TRM is maintained in an autophagy-independent manner even during starvation. We also found that when long-term antigen presentation is induced following intranasal immunization with adenovirus vectors. As a result, circulating memory T cells are continuously activated and differentiate into TRM in the lung. Understanding the mechanisms by which prolonged antigen presentation would help in the development of vaccination strategies to generate long-lived TRM.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：免疫学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07556seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000406/files/20K07556seika.pdf"},"version_id":"7192a435-f388-4eb0-97be-656c67092282"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07556","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07556/"},"subitem_award_titles":[{"subitem_award_title":"肺滞在型メモリーCD8T細胞長期維持法の開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Development of novel cancer immunotherapy by induction of epithelial-tropic CD8 T cells","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"免疫記憶","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"滞在型メモリー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"CD8T細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ウイルス感染防御","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺滞在型メモリーCD8T細胞長期維持法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of novel cancer immunotherapy by induction of epithelial-tropic CD8 T cells","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"肺滞在型メモリーCD8T細胞長期維持法の開発","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000406","relation_version_is_last":true,"title":["肺滞在型メモリーCD8T細胞長期維持法の開発"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-09T05:16:41.323643+00:00"}