{"created":"2023-11-15T07:17:21.707863+00:00","id":2000405,"links":{},"metadata":{"_buckets":{"deposit":"50862d12-3be3-41de-aac0-21e37ab0341b"},"_deposit":{"created_by":42,"id":"2000405","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000405"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000405","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"12","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"角田, 郁生","creatorNameLang":"ja"},{"creatorName":"Tsunoda, Ikuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"00261529","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"多発性硬化症は神経系における炎症を特徴とし、発病の機構があきらかでない指定難病の一つである。臨床疫学データ等から自己免疫素因のある個人が環境因子、特にウイルスに暴露された時に発症に至ると推察されているが、ウイルス感染に由来する何が発症を誘導するのか不明である。本研究の目的は、ウイルス感染が神経系の炎症の引き金となるメカニズムを明らかにすることである。我々は、ウイルスのゲノムであるRNA自身が、免疫系を過剰に活性化させうること、ウイルス感染は腸内フローラに変化をもたらし、これにより免疫系が活性化されること、さらにこれらの病原因子のそれぞれの役割の決定に有効な新規のビッグデータ解析法を見い出した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Multiple sclerosis (MS) is an inflammatory disease in the nervous system. Although the precise cause of MS is unknown, virus infections have been associated with the incidence of MS. Since we do not know how virus infections induce inflammation in the nervous system, we aimed to determine virus-induced pathogenic factors by which the immune cells could be overactivated, leading to immune cell infiltration in the nervous system and damaging the nerve fibers. We found that viral RNA genomes themselves can activate autoimmune responses, causing inflammation in the nervous system. We also found that viral infections altered the gut microbiota (flora), activating/changing several subsets of antibody responses. To determine the roles of these multiple immune factors, we applied several bioinformatics methods to big data. We found that exploratory factor analysis is the most useful method to determine not only the pathogenic factors but also protective factors.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：ウイルス学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07455seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000405/files/20K07455seika.pdf"},"version_id":"ab29b6bd-392f-453e-a3e5-6d2c02211c69"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07455","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07455/"},"subitem_award_titles":[{"subitem_award_title":"MS疾患モデルを用いたウイルス感染誘導性の自己免疫T細胞による中枢神経系炎症","subitem_award_title_language":"ja"},{"subitem_award_title":"Virus infection induces neuroinflammation by autoimmune T cells in the multiple sclerosis model","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"多発性硬化症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"動物モデル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"タイラーウイルス感染症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"中枢神経系","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自己抗体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MS疾患モデルを用いたウイルス感染誘導性の自己免疫T細胞による中枢神経系炎症","subitem_title_language":"ja"},{"subitem_title":"Virus infection induces neuroinflammation by autoimmune T cells in the multiple sclerosis model","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"MS疾患モデルを用いたウイルス感染誘導性の自己免疫T細胞による中枢神経系炎症","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000405","relation_version_is_last":true,"title":["MS疾患モデルを用いたウイルス感染誘導性の自己免疫T細胞による中枢神経系炎症"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-09T05:16:38.961434+00:00"}