{"created":"2023-11-15T07:17:17.825801+00:00","id":2000404,"links":{},"metadata":{"_buckets":{"deposit":"19e3a2ed-fd7f-46ef-a9c5-8b96dc97f0af"},"_deposit":{"created_by":42,"id":"2000404","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000404"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000404","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"8","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"萩山, 満","creatorNameLang":"ja"},{"creatorName":"Hagiyama, Man","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60632718","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"慢性腎臓病では尿細管間質病変の重篤度が残腎機能を規定するが、腎生検以外にその重篤度を知るのは難しい。慢性腎臓病では尿細管上皮のIgCAM型接着分子cell adhesion molecule 1（CADM1）の細胞外切断（shedding）が亢進しており、上皮アポトーシスを誘導する。shedding産物である細胞外断片NTFに注目し、尿中CADM1濃度を測定するサンドイッチELISAを樹立した。尿細管間質病変の重篤度と糸球体濾過率とは、尿中NTF濃度が高ければ高い程、非常に強く逆相関した。従って、尿中CADM1濃度が高い時は糸球体濾過率から尿細管傷害の重篤度を推測できると判明した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In chronic kidney disease (CKD), tubulointerstitial damage correlates with progressive decline in renal function, but it is difficult to monitor the severity without renal biopsy. Tumor suppressor CADM1/TSLC1, an IgCAM-type adhesion molecule, is expressed on renal tubular cells, and its increased ectodomain shedding is suggested to contribute to tubular degeneration. A sandwich ELISA for urinary CADM1 was developed using two anti-ectodomain antibodies. Urinary CADM1 concentrations in patients with CKD were measured. Renal biopsy specimens of all patients were pathologically scored for tubulointerstitial lesions using epithelial degeneration, interstitial inflammation, and fibrosis. There was a weak inverse correlation between pathological scores and elevated GFR (eGFR). Notably, this correlation gradually increased in patients with increasing CADM1 concentrations. CADM1 appeared to be a useful marker indicating tubulointerstitial damage from eGFR levels in CKD.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：実験病理","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07434seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000404/files/20K07434seika.pdf"},"version_id":"d7cf33c6-9f30-4061-949c-cf28bf834207"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07434","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07434/"},"subitem_award_titles":[{"subitem_award_title":"接着分子CADM1が基軸となる慢性腎臓病の尿細管間質病変形成","subitem_award_title_language":"ja"},{"subitem_award_title":"Tubulointerstitial lesion formation in chronic kidney disease mediated by renal adhesion molecule CADM1","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"上皮変性・アポトーシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性腎臓病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"接着分子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外切断","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"接着分子CADM1が基軸となる慢性腎臓病の尿細管間質病変形成","subitem_title_language":"ja"},{"subitem_title":"Tubulointerstitial lesion formation in chronic kidney disease mediated by renal adhesion molecule CADM1","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"接着分子CADM1が基軸となる慢性腎臓病の尿細管間質病変形成","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000404","relation_version_is_last":true,"title":["接着分子CADM1が基軸となる慢性腎臓病の尿細管間質病変形成"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:17.383123+00:00"}