{"created":"2023-11-15T07:17:07.567290+00:00","id":2000401,"links":{},"metadata":{"_buckets":{"deposit":"97b4bbac-84fe-41c9-bcce-d980c418611c"},"_deposit":{"created_by":42,"id":"2000401","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000401"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000401","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15301","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"岡山大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"勅使川原, 匡","creatorNameLang":"ja"},{"creatorName":"Teshigawara, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40403737","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"15301","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"岡山大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"王, 登莉","creatorNameLang":"ja"},{"creatorName":"Wang, Dengli","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40815693","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"7","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"和氣, 秀徳","creatorNameLang":"ja"},{"creatorName":"Wake, Hidenori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60570520","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"敗血症病態の増悪化に関与する2価鉄イオンによる血管内皮細胞障害は、2価鉄イオンによる小胞体ストレス応答よりミトコンドリアが障害され、その結果発生するミトコンドリア由来活性酸素により細胞膜が酸化し、膜が傷害されることで引き起こされることが明らかとなった。また、血漿糖タンパク質Histidine-rich glycoprotein(HRG)は、上記2価鉄イオンによる血管内皮細胞障害において、小胞体ストレス応答を抑制することにより、細胞保護効果を発揮することも明らかにした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We have demonstrated that divalent iron ion-induced vascular endothelial cell damage, which is involved in the exacerbation of sepsis, is caused by the cell membrane peroxidation damage by mitochondria-derived reactive oxygen species generated as a result of mitochondrial damage due to endoplasmic reticulum stress response by divalent iron ion stimulation. In addition, plasma glycoprotein Histidine-rich glycoprotein (HRG) was found to exert cytoprotective effects by suppressing the endoplasmic reticulum stress response induced by divalent iron ion in vascular endothelial cell damage.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：Pharmacology","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07290seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000401/files/20K07290seika.pdf"},"version_id":"33c97e2c-eb80-446b-a28f-c5e43830999c"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07290","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07290/"},"subitem_award_titles":[{"subitem_award_title":"敗血症関連DAMPs拮抗因子HRGの血管保護作用機序の解明","subitem_award_title_language":"ja"},{"subitem_award_title":"Elucidation of the vasoprotective mechanism of sepsis-associated DAMPs antagonist HRG","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"高ヒスチジン糖タンパク質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"敗血症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"2価鉄イオン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞死","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"敗血症関連DAMPs拮抗因子HRGの血管保護作用機序の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the vasoprotective mechanism of sepsis-associated DAMPs antagonist HRG","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"敗血症関連DAMPs拮抗因子HRGの血管保護作用機序の解明","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000401","relation_version_is_last":true,"title":["敗血症関連DAMPs拮抗因子HRGの血管保護作用機序の解明"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-09T05:16:28.025041+00:00"}