{"created":"2023-11-15T07:16:47.933330+00:00","id":2000396,"links":{},"metadata":{"_buckets":{"deposit":"c125741e-f2dc-4491-a873-1cd11213aea8"},"_deposit":{"created_by":42,"id":"2000396","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000396"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000396","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378692288":{"attribute_name":"研究協力者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"宮澤, 正顯","creatorNameLang":"ja"},{"creatorName":"Miyazawa, Masaaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60167757","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"河原, 佐智代","creatorNameLang":"ja"},{"creatorName":"Kawahara, Sachiyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60297629","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"博多, 義之","creatorNameLang":"ja"},{"creatorName":"Hakata, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30344500","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"6","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"月本, 翔太","creatorNameLang":"ja"},{"creatorName":"Tsukimoto, Shota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40790762","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"APOBEC3はT細胞に発現は大変少なく、胚中心B細胞に強発現していること、そしてAPOBEC3は核以外の部分に存在していることをフローサイトメトリーおよび免疫組織学的染色で示すことができた。また造血幹細胞からの分化段階において、細胞障害性T細胞とヘルパーT細胞の分化でAPOBEC3タンパク質の発現に差があること、胸腺内のリンパ球前駆細胞の比較的早い段階でAPOBEC3タンパク質の発現が見られることが胸腺で見ることができた。また骨髄のような造血幹細胞から分化を始めた初期の段階ではAPOBEC3の発現は認められなかった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Flow cytometry and immunohistological staining showed that APOBEC3 is very poorly expressed on T cells and strongly expressed on germinal center B cells, and that APOBEC3 is present outside the nucleus. In the thymus, APOBEC3 protein is expressed relatively early in the differentiation of lymphoid progenitors in the thymus, indicating that APOBEC3 protein is differentially expressed in cytotoxic T cells and helper T cells during differentiation from HSCs. APOBEC3 expression was not observed in the early stages of differentiation from hematopoietic stem cells, such as in the bone marrow.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：免疫学　麻酔科学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"19K17844seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000396/files/19K17844seika.pdf"},"version_id":"0185cc97-80dc-4a57-8a46-ebd27d496c03"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"19K17844","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17844/"},"subitem_award_titles":[{"subitem_award_title":"APOBEC3・AID二重欠損マウスを用いた白血病疾患モデルの構築と機能解析","subitem_award_title_language":"ja"},{"subitem_award_title":"The functional analysis of leukemia disease and the construction of this disease model using APOBEC3/AID double knockout mices","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"APOBEC3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"胚中心B細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"FLAGノックインマウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"造血幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨髄球系前駆細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ球系前駆細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"胸腺","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"APOBEC3・AID二重欠損マウスを用いた白血病疾患モデルの構築と機能解析","subitem_title_language":"ja"},{"subitem_title":"The functional analysis of leukemia disease and the construction of this disease model using APOBEC3/AID double knockout mices","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"APOBEC3・AID二重欠損マウスを用いた白血病疾患モデルの構築と機能解析","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000396","relation_version_is_last":true,"title":["APOBEC3・AID二重欠損マウスを用いた白血病疾患モデルの構築と機能解析"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:14.850800+00:00"}