{"created":"2023-11-15T07:16:40.346430+00:00","id":2000394,"links":{},"metadata":{"_buckets":{"deposit":"d5ee8b2d-5f9a-45dd-9636-a3920f370db4"},"_deposit":{"created_by":42,"id":"2000394","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000394"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000394","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中尾, 慎一","creatorNameLang":"ja"},{"creatorName":"Nakao, shin-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10207714","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"7","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"大田, 典之","creatorNameLang":"ja"},{"creatorName":"Ohta, Noriyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60379162","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"樹状細胞（DC）は適応免疫応答の制御に重要な役割を担っている。TSPOは免疫細胞に影響を与えるが、TSPOリガンドがDCに及ぼす影響については明らかにされていない。DCを介した免疫応答に対するTSPOの免疫調節特性を検討した。TSPOリガンドは、マウスDCから副刺激分子の発現を抑制した。エチフォキシンで処理されたDCは、インターロイキン12の分泌量も減少した。T細胞との混合細胞培養でマウスのT細胞のTh1への分化を抑制した。TSPOリガンド処理したDCは、接触過敏反応を阻害した。これはTSPOシグナルへの介入による炎症性疾患の制御の可能性を示唆する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Dendritic cells (DCs) play an important role in the regulation of adaptive immune responses; TSPO affects immune cells, but the effects of TSPO ligands on DCs are not known; the immunomodulatory properties of TSPO on DC-mediated immune responses were investigated. The TSPO ligand suppressed the expression of paracrine molecules from mouse DCs. Ethifoxin-treated DCs also decreased secretion of interleukin-12, inhibited differentiation of mouse T cells to Th1 in mixed cell culture with T cells, and inhibited contact hypersensitivity responses in TSPO ligand-treated DCs. This suggests the possibility of controlling inflammatory diseases by intervening in TSPO signaling.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：麻酔科学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"19K09387seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000394/files/19K09387seika.pdf"},"version_id":"136f26e6-8616-4e25-9504-12501d927b8c"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"19K09387","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09387/"},"subitem_award_titles":[{"subitem_award_title":"向精神薬による酸化ストレスの制御を介した免疫コントロール","subitem_award_title_language":"ja"},{"subitem_award_title":"The regulation of immune response by anti-psychotics via oxidative stress","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"樹状細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Translocator protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"接触過敏症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-12","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"副刺激分子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"向精神薬による酸化ストレスの制御を介した免疫コントロール","subitem_title_language":"ja"},{"subitem_title":"The regulation of immune response by anti-psychotics via oxidative stress","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"向精神薬による酸化ストレスの制御を介した免疫コントロール","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000394","relation_version_is_last":true,"title":["向精神薬による酸化ストレスの制御を介した免疫コントロール"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:11.168766+00:00"}