{"created":"2023-11-15T07:16:32.008985+00:00","id":2000392,"links":{},"metadata":{"_buckets":{"deposit":"f33b187e-87ab-4a61-9ea1-8ea7dc329662"},"_deposit":{"created_by":42,"id":"2000392","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000392"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000392","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"14401","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"大阪大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"三善, 英知","creatorNameLang":"ja"},{"creatorName":"Miyoshi, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20322183","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"14401","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"大阪大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"野々村, 祝夫","creatorNameLang":"ja"},{"creatorName":"Nonomura, Norio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30263263","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"9","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"藤田, 和利","creatorNameLang":"ja"},{"creatorName":"Fujita, Kazutoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50636181","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"フコシル化は癌および炎症における重要な糖鎖修飾の一つであり、 Core型、Lewis型、H型の3種類存在する。マイクロキャピラリー電気泳動免疫蛍光測定装置を用いて血中のcore型フコシル化PSAを測定するため測定キットの開発を行った。Core型フコシル化PSAは前立腺生検陰性患者と比べ前立腺癌患者で有意に上昇していた。またGleason scoreとも関連を認め、Gleson score 7以上の前立腺癌ではGleason score 6及び生検陰性群と比べても有意に上昇していた。またS2, 3PSAと同時測定することにより高リスク前立腺癌診断の精度が更にあがった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Fucosylation is one of the important glycosylation modifications in cancer and inflammation, and there are three types of fucosylation: Core, Lewis, and H-type. We developed a kit to measure core-type fucosylated PSA in blood using a microcapillary electrophoresis immunofluorescence assay, and found that core-type fucosylated PSA was significantly elevated in prostate cancer patients compared to prostate biopsy-negative patients. Core-type fucosylated PSA was also significantly elevated in prostate cancer patients with a Gleason score of 7 or higher, compared with Gleason score 6 and biopsy negative patients. Simultaneous measurement of S2, 3 PSA with core-type fucosylated PSA further improved the accuracy of diagnosis of high-risk prostate cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：前立腺癌","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"18K09132seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000392/files/18K09132seika.pdf"},"version_id":"e8d62fab-4695-466e-ad9e-1c46b9182b9e"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"18K09132","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K09132/"},"subitem_award_titles":[{"subitem_award_title":"高リスク前立腺癌におけるフコシル化タンパクの解析及び革新的治療法の開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Analysis of fucosylated protein of high risk prostate cancer and the development of novel therapy","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"糖鎖","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"PSA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高リスク前立腺癌におけるフコシル化タンパクの解析及び革新的治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Analysis of fucosylated protein of high risk prostate cancer and the development of novel therapy","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"高リスク前立腺癌におけるフコシル化タンパクの解析及び革新的治療法の開発","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000392","relation_version_is_last":true,"title":["高リスク前立腺癌におけるフコシル化タンパクの解析及び革新的治療法の開発"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:12.500277+00:00"}