{"created":"2023-11-15T07:16:13.060602+00:00","id":2000388,"links":{},"metadata":{"_buckets":{"deposit":"a232a97f-9ea5-4ad5-bca5-284cb215e570"},"_deposit":{"created_by":42,"id":"2000388","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000388"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000388","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"西尾, 和人","creatorNameLang":"ja"},{"creatorName":"Nishio, 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Noriomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20452336","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"(i) 卵巣癌において、上皮間葉転換が骨髄由来免疫抑制細胞の腫瘍内への集積と腫瘍免疫抑制をもたらしていることを明らかにした。(ii) 腫瘍内不均一性が予後不良に関わっていることを明らかにした。(iii) 卵巣癌における抗VEGF抗体の治療抵抗性が低酸素による骨髄由来免疫抑制細胞の集積によることを示した。(iv) DNA相同組み替え修復機構の異常について包括的な解析を行った。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We revealed the following findings. (i) Epithelial-mesenchymal transition results in the accumulation of bone marrow-derived myeloid suppressor cells (MDSC) within the tumour and tumour immunosuppression in ovarian cancer. (ii) Intratumoural heterogeneity in ovarian high-grade serous carcinoma is associated with poor prognosis. (iii) Resistance to anti-VEGF antibody treatment in ovarian cancer was due to hypoxia-induced accumulation of MDSC. (iv) A comprehensive analysis of abnormalities in DNA homologous recombination repair mechanisms was carried out.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：婦人科腫瘍学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"18H02947seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000388/files/18H02947seika.pdf"},"version_id":"bbf2b828-b767-40a4-a243-ee8507dd9344"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"18H02947","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02947/"},"subitem_award_titles":[{"subitem_award_title":"卵巣癌における腫瘍内不均一性の解析に基づく新規治療法の開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Development of new treatment for ovarian cancer based on intratumor heterogeneity","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"卵巣癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍内不均一性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍免疫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA修復機構","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"卵巣癌における腫瘍内不均一性の解析に基づく新規治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of new treatment for ovarian cancer based on intratumor heterogeneity","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"卵巣癌における腫瘍内不均一性の解析に基づく新規治療法の開発","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000388","relation_version_is_last":true,"title":["卵巣癌における腫瘍内不均一性の解析に基づく新規治療法の開発"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:19.047568+00:00"}