{"created":"2023-11-15T07:16:13.059470+00:00","id":2000387,"links":{},"metadata":{"_buckets":{"deposit":"4b8277a0-48bf-41d0-a610-d4857e5ddde8"},"_deposit":{"created_by":42,"id":"2000387","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000387"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000387","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"6","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"高橋, 彩","creatorNameLang":"ja"},{"creatorName":"Takahashi, Aya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70460889","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Endo180は間葉系細胞に発現し、断片化コラーゲンの取り込みに関与するコラーゲンレセプターのひとつである。本研究では、角膜線維芽細胞によるコラーゲンゲル収縮は抗Endo180抗体により有意に抑制され、Endo180が角膜線維芽細胞によるコラーゲンゲル収縮に関与していることが明らかになった。またEndo180はuPAにより切断され、コラーゲンと角膜線維芽細胞の相互作用を抑制することによりTGFβ/Smad3 signalを減弱させ、αSMAの発現を抑制的に制御することが明らかになった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Endo180 is a receptor for collagen that mediates its cellular internalization and also known as urokinase-type plasminogen activator (uPA) receptor-associated protein (uPARAP). In this study, anti-Endo180 antibody significantly inhibited the gel contraction induced by corneal fibroblasts, suggesting that Endo180 directly participate collagen gel contraction by corneal fibroblasts. We also found that Endo180 is cleaved by uPA and attenuates TGF β/Smad3 signal by suppressing the interaction between collagen and corneal fibroblasts, and negatively regulates αSMA expression.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：角膜","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-13"}],"filename":"20K18401seika.pdf","filesize":[{"value":"520 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000387/files/20K18401seika.pdf"},"version_id":"72acbca9-876a-410f-94b0-731cdf7a4f52"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K18401","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K18401/"},"subitem_award_titles":[{"subitem_award_title":"Endo180が角膜実質細胞におけるコラーゲン収縮能に果たす役割","subitem_award_title_language":"ja"},{"subitem_award_title":"Role for the Endo180 in collagen gel contraction mediated by corneal fibroblasts","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Endo180","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"コラーゲン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"角膜実質細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"角膜線維芽細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"uPA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TGFβ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"αSMA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Endo180が角膜実質細胞におけるコラーゲン収縮能に果たす役割","subitem_title_language":"ja"},{"subitem_title":"Role for the Endo180 in collagen gel contraction mediated by corneal fibroblasts","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"Endo180が角膜実質細胞におけるコラーゲン収縮能に果たす役割","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-15"},"publish_date":"2023-11-15","publish_status":"0","recid":"2000387","relation_version_is_last":true,"title":["Endo180が角膜実質細胞におけるコラーゲン収縮能に果たす役割"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:13.564093+00:00"}