{"created":"2023-11-08T06:05:04.453110+00:00","id":2000382,"links":{},"metadata":{"_buckets":{"deposit":"80d0ae4d-4d2d-4408-9a59-90e1bd9ec50c"},"_deposit":{"created_by":42,"id":"2000382","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000382"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000382","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"4","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"佐久間, 圭一朗","creatorNameLang":"ja"},{"creatorName":"Sakuma, Keiichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90402891","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究課題では、肺腺がん細胞の一次線毛発現制御分子であるKATNAL2(katanin catalytic subunit A1 like 2)に関して、がん幹細胞との関係および治療標的としての可能性を検討した。がん幹細胞との関係については、KATNAL2陽性細胞はG0期とは異なる細胞周期における静止が示唆され、幹細胞マーカー陽性細胞とも明確な一致を認めなかった。治療標的としての可能性については、KATNAL2遺伝子をノックアウトすると一次線毛の短縮ないし消失を認めると同時に、一部の抗腫瘍薬に対する感受性の増加を認めた。以上の結果から、KATNAL2標的薬と既存薬の併用療法の可能性が示された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"This study for KATNAL2 (katanin catalytic subunit A1 like 2), newly identified ciliogenesis-regulating protein in lung adenocarcinoma cells, has been performed to assess its involvement in cancer stemness as well as its utility as a therapeutic target. We found that ciliated A549 cells show cell cycle arrest at a different point from quiescent cancer stem cells staying at G0-G1 arrest. Furthermore, coincidence was not observed between ciliary marker expression and cancer stem cell marker expression. Knockout of the KATNAL2 gene inhibited ciliary extension and increased the sensitivity to some anticancer agents targeting cell proliferation. These results suggest a potential effect of KATNAL2-targeted drug when used in combination with currently-used agents.\n\n","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：腫瘍生物学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07581seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000382/files/20K07581seika.pdf"},"version_id":"a748972e-0ff6-4ce9-bc8e-bab5feb8d5cc"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07581","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07581/"},"subitem_award_titles":[{"subitem_award_title":"新規同定一次線毛発現制御分子KATNAL2は肺腺癌幹細胞の治療標的となり得るか？","subitem_award_title_language":"ja"},{"subitem_award_title":"Assessment of the utility of KATNAL2 as a therapeutic target in lung cancer stem cells\n","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺腺がん     ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"一次線毛     ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規同定一次線毛発現制御分子KATNAL2は肺腺癌幹細胞の治療標的となり得るか?\n\n","subitem_title_language":"ja"},{"subitem_title":"Assessment of the utility of KATNAL2 as a therapeutic target in lung cancer stem cells","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"新規同定一次線毛発現制御分子KATNAL2は肺腺癌幹細胞の治療標的となり得るか?\n\n","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000382","relation_version_is_last":true,"title":["新規同定一次線毛発現制御分子KATNAL2は肺腺癌幹細胞の治療標的となり得るか?\n\n"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:22.776363+00:00"}