{"created":"2023-11-08T06:01:01.189148+00:00","id":2000363,"links":{},"metadata":{"_buckets":{"deposit":"e0f84228-ca25-4277-9ab3-3a84315c8d38"},"_deposit":{"created_by":42,"id":"2000363","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000363"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000363","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"岸田, 邦博","creatorNameLang":"ja"},{"creatorName":"Kishida, Kunihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30412703","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"5","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"永井, 宏平","creatorNameLang":"ja"},{"creatorName":"Nagai, Kouhei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70500578","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"SWATH質量分析法は、臓器などに含まれる数百から数千種類のタンパク質を同時に、かつ精密に定量することができる分析手法である。本研究では高脂肪食を5週間摂取させて極初期のメタボリックシンドロームの状態にしたマウスの肝臓や脂肪組織中のタンパク質の網羅的な定量解析を行った。その結果、極初期のメタボロックシンドロームにおいては、糖新生の進行が抑制されており、これが代謝異常の引き金となっている可能性が示され。また、肝臓におけるUSP5やEpiplakin, 脂肪組織におけるASPHなどの新規な肥満関連因子を発見した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"SWATH mass spectrometry is an analytical technique that can simultaneously and precisely quantify hundreds to thousands of proteins in organs and other biological samples. In this study, we performed a comprehensive quantitative analysis of proteins in the liver and adipose tissue of mice that were fed a high-fat diet for 5 weeks and were in a state of very early metabolic syndrome. The results showed that the progression of  glycogenesis is suppressed in the very early stage of the metabolic syndrome, which may trigger the metabolic abnormalities. We also found novel obesity-related factors such as USP5 and Epiplakin in the liver and ASPH in adipose tissue.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：プロテオミクス","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K11616seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000363/files/20K11616seika.pdf"},"version_id":"7654a314-2606-4b5c-900e-67130ecfd64e"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K11616","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K11616/"},"subitem_award_titles":[{"subitem_award_title":"高精度網羅的タンパク質定量法によるメタボリックシンドロームの発生機序の全体像解明","subitem_award_title_language":"ja"},{"subitem_award_title":"Elucidation of the overall mechanism of metabolic syndrome by high-precision comprehensive protein quantification","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"プロテオーム解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メタボリックシンドローム","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"肝臓","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪組織","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高精度網羅的タンパク質定量法によるメタボリックシンドロームの発生機序の全体像解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the overall mechanism of metabolic syndrome by high-precision comprehensive protein quantification","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"高精度網羅的タンパク質定量法によるメタボリックシンドロームの発生機序の全体像解明","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000363","relation_version_is_last":true,"title":["高精度網羅的タンパク質定量法によるメタボリックシンドロームの発生機序の全体像解明"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-02-09T05:14:50.658603+00:00"}