{"created":"2023-11-08T01:38:39.322003+00:00","id":2000326,"links":{},"metadata":{"_buckets":{"deposit":"bc8275f8-8b1e-4078-8f55-ba6a5b66127b"},"_deposit":{"created_by":42,"id":"2000326","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000326"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000326","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"9","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"早坂, 晴子","creatorNameLang":"ja"},{"creatorName":"Hayasaka, Haruko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70379246","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"全身で恒常的に Dach1 を発現する遺伝子改変マウスを用いて、リンパ節血管における Dach1 遺伝子の機能を解析した。リンパ節ストローマ細胞を解析したところ、Dach1全身発現マウスにおいて高内皮細静脈血管内皮細胞割合の増加がみられた。一方、 汎血管内皮細胞マーカー陽性血管内皮細胞の割合に変化は見られなかった。次世代シーケンス解析から、Dach1全身発現マウスでは高内皮細静脈接着分子発現に関連する遺伝子発現に違いが見られたことから、Dach1 はリンパ節血管内皮細胞において接着分子発現を調節し、血管成熟分化に関与する可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In the present study, we analyzed the transgenic mice that ubiquitously express Dach1 gene. In lymph nodes, percentage of high-endothelial microvascular endothelial cells was increased in the Dach1 transgenic mice. In contrast, there was no change in the percentage of pan-endothelial marker-positive vascular endothelial cells. Next generation sequencing analysis showed that Dach1 transgenic mice showed differential expression of genes associated with high endothelial venules, suggesting that Dach1 regulates differentiation of lymph node vascular endothelial cells and vascular maturation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：組織分化","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"19K07278seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000326/files/19K07278seika.pdf"},"version_id":"3617bfce-4143-427b-a1f8-7bb8a546564e"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"19K07278","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07278/"},"subitem_award_titles":[{"subitem_award_title":"転写因子 Dach1 による組織特異的な血管内皮細胞分化調節メカニズム","subitem_award_title_language":"ja"},{"subitem_award_title":"Mechanism of tissue-specific differentiation of vascular endothelial cells by Dach1 expression","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血管形成","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ節","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現マウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"転写因子 Dach1 による組織特異的な血管内皮細胞分化調節メカニズム","subitem_title_language":"ja"},{"subitem_title":"Mechanism of tissue-specific differentiation of vascular endothelial cells by Dach1 expression","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"転写因子 Dach1 による組織特異的な血管内皮細胞分化調節メカニズム","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000326","relation_version_is_last":true,"title":["転写因子 Dach1 による組織特異的な血管内皮細胞分化調節メカニズム"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:25.324314+00:00"}