{"created":"2023-11-08T01:38:07.306061+00:00","id":2000318,"links":{},"metadata":{"_buckets":{"deposit":"4a4e75a5-4047-4394-9fda-fac3dc9b5c88"},"_deposit":{"created_by":42,"id":"2000318","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000318"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000318","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"24405","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"大阪公立大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"立花, 太郎","creatorNameLang":"ja"},{"creatorName":"Tachibana, Taro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"80311752","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"7","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"今野, 大治郎","creatorNameLang":"ja"},{"creatorName":"Konno, Daijiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"00362715","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究では、我々がこれまで培ってきた、ラット腸骨リンパ節法を用いたモノクローナル抗体作製技術および1細胞ラビットモノクローナル組換え抗体作製技術を応用・発展させ、グリオーマ幹細胞および膵臓がん幹細胞をモデルとして、新規がん幹細胞表面マーカー分子の同定を試みた。その結果、これらの幹細胞の細胞表面抗原を特異的に認識する新規ラットモノクローナル抗体を複数単離することに成功し、新規の抗体医薬品およびがん免疫療法の開発シーズとなり得る抗体を取得した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we attempted to identify novel cancer stem cell surface marker molecules using glioma stem cells and pancreatic cancer stem cells as models by applying and developing the monoclonal antibody production technology using the rat iliac lymph node method and one-cell rabbit monoclonal recombinant antibody production technology we have developed so far. As a result, we succeeded in isolating several novel rat monoclonal antibodies that specifically recognize the cell surface antigens of these stem cells, and obtained antibodies that could serve as seeds for the development of novel antibody drugs and cancer immunotherapy.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：分子細胞生物学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"19K07776seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000318/files/19K07776seika.pdf"},"version_id":"4f467327-87e6-4add-8ea3-05bf2e78c0fb"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"19K07776","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07776/"},"subitem_award_titles":[{"subitem_award_title":"1細胞ラビット組換え抗体作製技術を用いた新規がん幹細胞表面マーカー分子の探索","subitem_award_title_language":"ja"},{"subitem_award_title":"Identification of novel cell surface antigens for cancer stem cells using single-cell technology","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗体医薬品","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"モノクローナル抗体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"組換え抗体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞表面抗原","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1細胞ラビット組換え抗体作製技術を用いた新規がん幹細胞表面マーカー分子の探索","subitem_title_language":"ja"},{"subitem_title":"Identification of novel cell surface antigens for cancer stem cells using single-cell technology","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"1細胞ラビット組換え抗体作製技術を用いた新規がん幹細胞表面マーカー分子の探索","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000318","relation_version_is_last":true,"title":["1細胞ラビット組換え抗体作製技術を用いた新規がん幹細胞表面マーカー分子の探索"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:21.289795+00:00"}