{"created":"2023-11-08T01:37:42.234565+00:00","id":2000312,"links":{},"metadata":{"_buckets":{"deposit":"0f6f5edc-e367-4f7d-9376-ae2ec71d7876"},"_deposit":{"created_by":42,"id":"2000312","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000312"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000312","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"7","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"森山, 麻里子","creatorNameLang":"ja"},{"creatorName":"Moriyama, Mariko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40595295","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究では、表皮特異的Hes1コンディショナルノックアウト(Hes1cKOepi)マウスを作成し、イミキモドによる乾癬の誘発を行ったところ、当該マウスでは乾癬の特徴的病態の悪化が観察された。さらに、表皮に発現する遺伝子の網羅的解析により、Hes1cKOepiマウスでは表皮ケラチノサイトからの炎症系サイトカイン遺伝子群の発現が増加していることが明らかとなった。以上の結果は、Hes1が表皮における免疫調節遺伝子発現に関与し、免疫細胞の遊走や活性化を抑制することで過剰な皮膚免疫を抑え、正常な皮膚の恒常性の維持に寄与している可能性を示している。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we found that Hes1 expression in interfollicular epidermis was significantly increased in Imiquimod (IMQ)-induced, psoriasis-like legional epidermis. By analyzing tamoxifen-inducible, epidermal-specific Hes1 knockout (Hes1Δepi) mice, deletion of Hes1 resulted in the exacerbation of psoriasis when treated with IMQ. Transcriptome analysis revealed that the expression of inflammatory cytokine genes were significantly upregulated in Hes1Δepi epidermal keratinocytes. These results indicate that epidermal expression of Hes1 is involved in immunomodulatory gene expression in the epidermal keratinocytes and may contribute to the maintenance of skin homeostasis by suppressing excessive skin immunity through suppressing immune cell migration or activation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：皮膚科学、分子生物学、細胞生物学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K08662seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000312/files/20K08662seika.pdf"},"version_id":"fca68f2a-f790-40ce-9e55-9c4917641fdf"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K08662","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08662/"},"subitem_award_titles":[{"subitem_award_title":"表皮のNotchシグナルは皮膚免疫を調節するのか？","subitem_award_title_language":"ja"},{"subitem_award_title":"Roles of Notch signaling in the regulation of skin immune system","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Notchシグナル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"表皮","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"乾癬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"表皮のNotchシグナルは皮膚免疫を調節するのか？","subitem_title_language":"ja"},{"subitem_title":"Roles of Notch signaling in the regulation of skin immune system","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"表皮のNotchシグナルは皮膚免疫を調節するのか？","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000312","relation_version_is_last":true,"title":["表皮のNotchシグナルは皮膚免疫を調節するのか？"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:25.749560+00:00"}