{"created":"2023-11-08T01:37:38.429316+00:00","id":2000311,"links":{},"metadata":{"_buckets":{"deposit":"c4151ee3-7c96-44de-aba2-b97937de8fac"},"_deposit":{"created_by":42,"id":"2000311","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000311"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000311","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378692288":{"attribute_name":"研究協力者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"西田, 升三","creatorNameLang":"ja"},{"creatorName":"NISHIDA, Shozo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40208187","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"武田, 朋也","creatorNameLang":"ja"},{"creatorName":"TAKEDA, Tomoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20734031","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"11","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"椿, 正寛","creatorNameLang":"ja"},{"creatorName":"TSUBAKI, Masanobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30434856","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"オキサリプラチン、パクリタキセル及びボルテゾミブ誘発末梢神経障害の発症メカニズムについて解析を行い、腰椎におけるERK経路の活性化が関与することを見出した。また、MEK/ERK経路を阻害する分子標的薬によりERK経路の抑制を介してオキサリプラチン、パクリタキセル及びボルテゾミブ誘発末梢神経障害を阻害することを明らかにした。以上の結果は、臨床におけるオキサリプラチン、パクリタキセル及びボルテゾミブ誘発末梢神経障害発症時における治療に貢献できる可能性が考えられる。なお、本研究成果は主な発表論文の項に全てまとめてある。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We investigated the mechanisms of oxaliplatin, paclitaxel, and bortezomib-induced neuropathy, and found that activation of the ERK pathway in the lumbar region is involved. We also found that molecularly targeted drugs inhibition of the MEK/ERK pathway prevented oxaliplatin-, paclitaxel-, and bortezomib-induced neuropathy via inhibition of the ERK pathway. These results may contribute to the treatment of oxaliplatin-, paclitaxel-, and bortezomib-induced neuropathy in clinical practice. The results of this study are summarized in the main publications section.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：薬物治療学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07168seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000311/files/20K07168seika.pdf"},"version_id":"38d06537-9cf6-473d-bbd8-f5488af8cccb"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07168","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07168/"},"subitem_award_titles":[{"subitem_award_title":"がん化学療法誘発末梢神経障害の機序解明と新規治療法の開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Investigation of the mechanism of chemotherapy-induced peripheral neuropathy and development of new therapeutic strategy","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗がん剤誘発末梢神経障害","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"分子標的薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん化学療法誘発末梢神経障害の機序解明と新規治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Investigation of the mechanism of chemotherapy-induced peripheral neuropathy and development of new therapeutic strategy","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"がん化学療法誘発末梢神経障害の機序解明と新規治療法の開発","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000311","relation_version_is_last":true,"title":["がん化学療法誘発末梢神経障害の機序解明と新規治療法の開発"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:24.882297+00:00"}