{"created":"2023-11-08T01:37:30.804085+00:00","id":2000309,"links":{},"metadata":{"_buckets":{"deposit":"073a8041-db2c-4169-8f99-d8b4b48c34d8"},"_deposit":{"created_by":42,"id":"2000309","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000309"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000309","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"松尾, 一彦","creatorNameLang":"ja"},{"creatorName":"Matsuo, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70615921","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"6","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中山, 隆志","creatorNameLang":"ja"},{"creatorName":"Nakayama, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60319663","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究は、乾癬におけるケモカイン受容体CCR4の役割の解明を目的とする。CCR4欠損マウスは、皮膚の肥厚や紅斑、鱗屑といった乾癬様病態の軽減および乾癬関連遺伝子の発現減少を示した。この時、病変皮膚および所属リンパ節において、Th17細胞が減少していた。さらに、所属リンパ節において、CCR4陽性のTh17細胞とCCL22産生の樹状細胞がクラスターを形成しており、CCR4欠損マウスでは、それが減少していた。また、選択的CCR4阻害薬でも同様の結果が得られた。以上より、CCR4は、所属リンパ節でのTh17細胞増殖に関与し、乾癬病態の発現に寄与する可能性が示された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In the present study, we examined the role of CCR4 in psoriasis. CCR4 deficiency caused the decrease in skin disease and expression levels of psoriasis-related genes. Furthermore, Th17 cells were reduced in the skin lesions and regional lymph nodes of CCR4 deficient mice. In the regional lymph nodes, CCR4-positive Th17 cells were clustered with CCL22-producing dendritic cells, and these clusters were decreased in CCR4 deficient mice. Similar results were observed in selective CCR4 antagonist-treated mice. These findings suggest that CCR4 would be involved in the pathology of psoriasis through the expansion of Th17 cells in the lymph nodes.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：免疫学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K08700seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000309/files/20K08700seika.pdf"},"version_id":"cbbc6b41-b6bb-466b-b0eb-83aed60d2358"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K08700","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08700/"},"subitem_award_titles":[{"subitem_award_title":"乾癬におけるケモカイン受容体CCR4を介したTh17細胞増殖の病理的役割の解明","subitem_award_title_language":"ja"},{"subitem_award_title":"Role of Th17 cell expansion through CCR4 in psoriasis","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"乾癬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"CCR4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th17","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"乾癬におけるケモカイン受容体CCR4を介したTh17細胞増殖の病理的役割の解明","subitem_title_language":"ja"},{"subitem_title":"Role of Th17 cell expansion through CCR4 in psoriasis","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"乾癬におけるケモカイン受容体CCR4を介したTh17細胞増殖の病理的役割の解明","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000309","relation_version_is_last":true,"title":["乾癬におけるケモカイン受容体CCR4を介したTh17細胞増殖の病理的役割の解明"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:10.665503+00:00"}