{"created":"2023-11-08T01:37:10.257107+00:00","id":2000304,"links":{},"metadata":{"_buckets":{"deposit":"3b7ab71f-f7eb-45d4-808f-2e43a7099703"},"_deposit":{"created_by":42,"id":"2000304","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000304"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000304","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中山, 隆志","creatorNameLang":"ja"},{"creatorName":"Nakayama, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"60319663","nameIdentifierScheme":"e-Rad"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"6","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"松尾, 一彦","creatorNameLang":"ja"},{"creatorName":"Matsuo, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70615921","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究において、CD70陽性樹状細胞が鼻腔内粘膜固有層に存在し、P2X1,2,4受容体を発現することを明らかにした。また、CD70陽性樹状細胞はαβ-ATPの刺激によりTh17細胞分化を促進した。さらに、モデル抗原OVAとともにαβ-ATPを経鼻投与したマウスにおいて、エフェクターフェーズだけでなく、メモリーフェーズにおいてCTLの誘導および抗腫瘍効果が認められ、P2受容体阻害剤であるsuraminの前投与により、上記の免疫応答は抑制された。これらの結果は、αβ-ATPはTh17細胞誘導を介してエフェクターおよびメモリーCTLを誘導できる粘膜免疫アジュバントとして有用であることを示唆している。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"We showed that (i) CD70+ dendritic cells (DCs) were present in the nasal lamina propria and expressed P2X1R, P2X2R and P2X4R; (ii) CD70+DCs but not CD70-DCs enhanced Th17 cell differentiation of cocultured splenic CD4+ T cells upon stimulation with αβ-ATP; (iii) mice intranasally immunized with ovalbumin (OVA) and αβ-ATP had increased OVA-specific Th17 cells and CTLs in the nasal lamina propria and regional lymph nodes at both an effector phase and a memory phase; (iv) mice intranasally immunized with OVA and αβ-ATP also inhibited E.G7-OVA tumor growth; (v) suramin, a broad-range inhibitor of P2 receptors, suppressed the increases of OVA-specific Th17 cells and CTLs, and antitumor effect. Collectively, αβ-ATP may be a promising mucosal adjuvant that promotes antigen-specific effector and memory CTL responses via CD70+ DC-mediated Th17 induction.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：免疫学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K08850seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000304/files/20K08850seika.pdf"},"version_id":"49fd2972-1b76-4cdd-8abc-270a00ced047"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K08850","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08850/"},"subitem_award_titles":[{"subitem_award_title":"P2受容体を標的としたメモリーCTL誘導ワクチンシステムの開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Memory CTL-inducing vaccine sistem targeting P2 recepors","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ワクチンアジュバント","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"CTL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th17","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"P2受容体を標的としたメモリーCTL誘導ワクチンシステムの開発","subitem_title_language":"ja"},{"subitem_title":"Memory CTL-inducing vaccine sistem targeting P2 recepors","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"P2受容体を標的としたメモリーCTL誘導ワクチンシステムの開発","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000304","relation_version_is_last":true,"title":["P2受容体を標的としたメモリーCTL誘導ワクチンシステムの開発"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:06.932233+00:00"}