{"created":"2023-11-08T01:37:06.278202+00:00","id":2000303,"links":{},"metadata":{"_buckets":{"deposit":"45e14fad-c444-4158-97f5-4da6cbde4c91"},"_deposit":{"created_by":42,"id":"2000303","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000303"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000303","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"22","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"佐藤, 亮介","creatorNameLang":"ja"},{"creatorName":"Satoh, Ryosuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"00635592","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"RNA顆粒制御因子の過剰発現に伴う『分裂酵母の細胞死』というシンプルな表現型を利用した、RNA顆粒の形成や崩壊といったダイナミクスに影響を与える遺伝子群・化合物群のスクリーニング系を立ち上げ実施した。その結果、分裂酵母のCキナーゼであるPck2が、高温ストレスにおいて自身のキナーゼ活性依存的にストレス顆粒に隔離されることを明らかにした。また、本スクリーニング系によって、ストレス顆粒の形成を促進・抑制する可能性がある化合物を取得した。本化合物によってストレス顆粒を初めとしたRNA顆粒の形成を制御することで、RNA顆粒の異常な形成が関わる疾患の新たな治療戦略になる可能性がある。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"I launched and conducted a screening system using a fission yeast cell death phenotype associated with the overexpression of RNA granule regulators to isolate genes and compounds that affect the dynamics of RNA granule formation and disassembly. As a result, the fission yeast C kinase Pck2 is sequestrated into stress granules in a kinase activity-dependent manner under heat shock conditions. Furthermore, through this screening system, compounds that have the potential to promote or suppress stress granule formation were identified. Regulating the formation of RNA granules, including stress granules, with these compounds may provide a novel therapeutic strategy for diseases associated with abnormal RNA granule formation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：分子生物学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K06494seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000303/files/20K06494seika.pdf"},"version_id":"8ec5c433-0fa9-4c44-8839-ea49c3957bc5"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K06494","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K06494/"},"subitem_award_titles":[{"subitem_award_title":"RNA顆粒ダイナミクスの制御機構解明と難治性疾患治療への応用","subitem_award_title_language":"ja"},{"subitem_award_title":"Elucidation of the regulatory mechanisms of RNA granule dynamics and its application to treatment of intractable diseases","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"RNA顆粒","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス顆粒","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"分裂酵母","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"液ー液相分離","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"LLPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PUF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"イノシトールリン脂質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNA顆粒ダイナミクスの制御機構解明と難治性疾患治療への応用","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the regulatory mechanisms of RNA granule dynamics and its application to treatment of intractable diseases","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"RNA顆粒ダイナミクスの制御機構解明と難治性疾患治療への応用","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000303","relation_version_is_last":true,"title":["RNA顆粒ダイナミクスの制御機構解明と難治性疾患治療への応用"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:05.862579+00:00"}