{"created":"2023-11-08T01:37:02.775896+00:00","id":2000302,"links":{},"metadata":{"_buckets":{"deposit":"43b5fd39-c0e8-4730-85db-922306df6bf9"},"_deposit":{"created_by":42,"id":"2000302","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000302"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000302","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"9","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"高崎, 輝恒","creatorNameLang":"ja"},{"creatorName":"Takasaki, Teruaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"30615539","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"分裂酵母を遺伝子改変して作成した「パーキンソン病モデル細胞」を用いた解析により、抗てんかん薬として知られるバルプロ酸がパーキンソン病モデル細胞の細胞障害を顕著に増悪させることを見出した。ヒト神経細胞由来のcDNAライブラリからαSyn凝集抑制因子を探索する試みについては良好な結果が得られなかったが、抗真菌作用をもつ化合物のひとつがαSynの凝集化の抑制にはたらくことを見出した。さらに、遺伝学的解析を通じて、エンドサイトーシスのプロセスがαSynの凝集化に深く関与することを見出した。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Analysis using \"Yest model of Parkinson's disease (PD)\" created by genetically-modified fission yeast revealed that valproic acid, which is an anti-epileptic drug, markedly exacerbated cytotoxicity in PD model cells. Although the attempt to search for αSyn aggregation suppressors from a cDNA library prepared from human neuronal cells did not yield favorable results, we found that one of the antifungal reagents works to suppress αSyn aggregation in fission yeast. Furthermore, through genetic analysis, we found that processes of endocytosis are deeply involved in αSyn aggregation.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：分子生物学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07058seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000302/files/20K07058seika.pdf"},"version_id":"49a2f99a-e997-4038-a65a-924c0d6be64e"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07058","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07058/"},"subitem_award_titles":[{"subitem_award_title":"ほ乳動物細胞が内包するαシヌクレイン蛋白質の凝集抑制機構の解明","subitem_award_title_language":"ja"},{"subitem_award_title":"Study of intrinsic inhibitory mechanisms for alpha synuclein aggregation","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"シヌクレイン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"synuclein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"パーキンソン病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"S. pombe","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ほ乳動物細胞が内包するαシヌクレイン蛋白質の凝集抑制機構の解明","subitem_title_language":"ja"},{"subitem_title":"Study of intrinsic inhibitory mechanisms for alpha synuclein aggregation","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"ほ乳動物細胞が内包するαシヌクレイン蛋白質の凝集抑制機構の解明","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000302","relation_version_is_last":true,"title":["ほ乳動物細胞が内包するαシヌクレイン蛋白質の凝集抑制機構の解明"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:49:06.731737+00:00"}