{"created":"2023-11-08T01:36:54.901510+00:00","id":2000300,"links":{},"metadata":{"_buckets":{"deposit":"6c7d68eb-647b-481d-a1bf-2505a4f2bb03"},"_deposit":{"created_by":42,"id":"2000300","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000300"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000300","sets":["14:2667:1697004343623"]},"author_link":[],"item_1693378644159":{"attribute_name":"研究分担者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"川畑, 篤史","creatorNameLang":"ja"},{"creatorName":"KAWABATA, Atsufumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20177728","nameIdentifierScheme":"e-Rad"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"坪田, 真帆","creatorNameLang":"ja"},{"creatorName":"TSUBOTA, Maho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90510123","nameIdentifierScheme":"e-Rad"}]}]},"item_1693378692288":{"attribute_name":"研究協力者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"豊岡, 尚樹","creatorNameLang":"ja"},{"creatorName":"TOYOOKA, Naoki","creatorNameLang":"en"}]}]},"item_1693381679919":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"report","resourceuri":"http://purl.org/coar/resource_type/c_93fc"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicNumberOfPages":"5","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2022)","bibliographic_titleLang":"ja"}]}]},"item_30001_creator2":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"34419","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"関口, 富美子","creatorNameLang":"ja"},{"creatorName":"SEKIGUCHI, Fumiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"90271410","nameIdentifierScheme":"e-Rad"}]}]},"item_30001_description8":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究では、生体内で硫化水素（H2S）を産生する酵素シスタチオニン-β-シンターゼ(CBS)の阻害が、がん化した形質細胞である多発性骨髄腫の細胞増殖を強く抑制することを明らかにした。さらに、パーキンソン病治療薬であるカルビドパがCBS阻害活性を有し、多発性骨髄腫の細胞死を誘起することを見出した。これらの結果は、多発性骨髄腫の抗がん剤治療に、カルビドパやその他のCBS阻害薬の追加が、抗がん剤の有効性を高められる可能性を示唆する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Our study has revealed that inhibition of cystathionine-β-synthase (CBS), an H2S-forming enzyme in a mammalian body, markedly suppresses cell proliferation of multiple myeloma, a cancer that forms in a type of white blood cell called a plasma cell. In addition, we have found that carbidopa, a medicine for Parkinson disease, possesses inhibitory activity of CBS, and induces cell death of multiple myeloma. The data suggest that additional medication of carbidopa or other CBS inhibitors to anticancer drugs for multiple myeloma enhances the efficacy of anticancer drugs.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"研究分野：薬理学","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"20K07079seika.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000300/files/20K07079seika.pdf"},"version_id":"cdc557ed-8f09-4b1b-ac95-6587eca44a9f"}]},"item_30001_funding_reference15":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07079","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07079/"},"subitem_award_titles":[{"subitem_award_title":"内因性硫化水素合成阻害による抗がん剤の有効性増大と副作用軽減の可能性について","subitem_award_title_language":"ja"},{"subitem_award_title":"Possibility for increase in efficacy and alleviation in adverse effect of anti-cancer drugs by inhibition of endogenous hydrogen sulfide synthesis","subitem_award_title_language":"en"}],"subitem_funder_names":[{"subitem_funder_name":"独立行政法人日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"硫化水素合成酵素","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シスタチオニン-β-シンターゼ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"CBS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"多発性骨髄腫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"芳香族L-アミノ酸脱炭酸酵素阻害薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"カルビドパ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"がん増殖抑制","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"CBS阻害薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"内因性硫化水素合成阻害による抗がん剤の有効性増大と副作用軽減の可能性について","subitem_title_language":"ja"},{"subitem_title":"Possibility for increase in efficacy and alleviation in adverse effect of anti-cancer drugs by inhibition of endogenous hydrogen sulfide synthesis","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"内因性硫化水素合成阻害による抗がん剤の有効性増大と副作用軽減の可能性について","item_type_id":"40001","owner":"42","path":["1697004343623"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-08"},"publish_date":"2023-11-08","publish_status":"0","recid":"2000300","relation_version_is_last":true,"title":["内因性硫化水素合成阻害による抗がん剤の有効性増大と副作用軽減の可能性について"],"weko_creator_id":"42","weko_shared_id":-1},"updated":"2024-10-23T00:48:27.523392+00:00"}