| アイテムタイプ |
紀要論文 / departmental bulletin paper(1) |
| 公開日 |
2024-01-30 |
| タイトル |
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|
タイトル |
Effects of amines on NMDA receptors |
|
言語 |
en |
| 作成者 |
YAMADA, Yasue
YABUKI, Tomo
NORIKANE, Kiyoto
HARADA, Naoki
ICHIKAWA, Keita
KISOI, Shogo
KUBOE, Yudai
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
amines, sake, NMDA receptor, Oocyte expression system |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
N-methyl-D-aspartic acid (NMDA) receptors are widely distributed in the central nervous system and play critical roles in synaptic plasticity and excitotoxicity. Memantine, one of the amines, is a partial agonist of the NMDA receptor and is used as medicine for treatment of Alzheimer’s disease. To find a new channel blocker of the NMDA receptor, the agonist and antagonist activities of amines contained in Japanese sake on the NMDA receptor were investigated. Polyamines are present at millimolar concentrations in cells and play important roles in aging, cell proliferation, gene expression and cellular stress. Various foods and beverages including fruits nuts, sake, wine and cheese contain amines. However, the precise biological functions of amines are still unclear. The effects of 12 amines contained in sake on GluN1/GluN2A and GluN1/GluN2B receptors were examined. Agmatine, tyramine, 2-phenylethylamine and 4 other amines inhibited the activity of both receptors. Putrescine inhibited the activity of only the GluN1/GluN2A receptor. Betaine and trimethylamine N-oxide inhibited the activity of only the GluN1/GluN2B receptor. Isoamylamine acted as an antagonist against the GluN1/GluN2B receptor but act as an activator for the GluN1/GluN2A receptor. The results indicated that amines contained in sake can be used as potential therapeutic agents for neural disorders such as anxiety and dementia. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
近畿大学工学部 |
|
言語 |
ja |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| ID登録 |
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|
ID登録 |
10.15100/0002000227 |
|
ID登録タイプ |
JaLC |
| 収録物識別子 |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434592X |
| 書誌情報 |
ja : 近畿大学工学部研究報告
en : Research reports of the Faculty of Engineering, Kindai University
号 57,
p. 61-67,
発行日 2024-02-20
|
AN00063799-20240220-0061.pdf
