{"created":"2023-09-25T06:51:57.807176+00:00","id":2000111,"links":{},"metadata":{"_buckets":{"deposit":"0acdaa2c-fb57-426b-8822-656b6913b26b"},"_deposit":{"created_by":42,"id":"2000111","owners":[42],"pid":{"revision_id":0,"type":"depid","value":"2000111"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:02000111","sets":["14:923:1477:1695623362015"]},"author_link":[],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"314","bibliographicPageStart":"307","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"乳癌の発生・進展・転移過程における染色体不安定性の生物学的意義を明らかにする目的で，蛍光in situ hybridization（FISH）法を用いて乳癌原発巣および乳癌に併存している乳腺症，また転移リンパ節巣のホルマリン固定パラフィン包埋切片から染色体数的異常を解析した．128例の乳癌原発巣の検体から1番染色体polysomyはdisomy乳癌に比べ有意に高頻度にリンパ節転移を認め(p<0.05)，また17番染色体aneusomyも有意に高頻度にリンパ節転移乳癌に認められた(p<0.05)．33例のリンパ節転移陽性乳癌の原発巣と転移リンパ節巣における1番，11番，17番染色体数的異常の比較検討では11番染色体aneusomyは原発巣に比べ転移リンパ節巣で有意に高頻度に認められた(p<0.05)．24例の45歳以下の乳癌と併存する乳腺症病変における解析では，2例において乳癌とそれに併存する乳腺症の両病変に17番染色体monosomyが認められ，この2例の乳腺症は組織学的にはproliferative lesion without atypiaであった．p53免疫染色は乳癌24例中9例にp53陽性がみられたが，併存する乳腺症ではすべて陰性であった．またP53免疫染色は17番染色体数的異常との関連は認められなかった．これらのことから，1番，17番染色体のaneusomyは乳癌リンパ節転移過程で腫瘍細胞の原発巣からの離脱機構に関与し，11番染色体aneusomyは転移巣での浸潤および増殖に関与していると考えられる．そして17番染色体monosomyは乳癌発生の初期過程への関与が，またp53異常は乳癌発生・進展の後期過程での関与が示唆される．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会","subitem_publisher_language":"ja"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki Unversity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"平井, 昭彦","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki Unversity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"今西, 幸仁","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学医学部奈良病院","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"太田, 善夫","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki Unversity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"乾, 浩己","creatorNameLang":"ja"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kinki Unversity","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"綿谷, 正弘","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"AN00063584-20011225-0307.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://kindai.repo.nii.ac.jp/record/2000111/files/AN00063584-20011225-0307.pdf"},"version_id":"62ea6dbe-bd7a-4c1a-a594-cd27b1fe0fae"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"乳癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"染色体数的異常","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"乳癌 carcinogenesis","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"乳腺症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"p53遺伝子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"FISH法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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