{"created":"2023-06-20T16:47:59.190145+00:00","id":19773,"links":{},"metadata":{"_buckets":{"deposit":"85e1285e-d602-4451-9b44-842504a346d0"},"_deposit":{"created_by":3,"id":"19773","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19773"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019773","sets":["14:2667:4459"]},"author_link":["33627","33626"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：ナンヨウアブラギリ（Jatropha curcas）はその種子中にバイオディーゼルの生産に適した流動性の高い中性脂質を50％以上含み、次世代のバイオ燃料の原料作物として期待されている熱帯性灌木である。一方本植物は油脂以外に二次代謝産物として発がんプロモーション活性を持つホルボールエステル類を生産する。我々は、本植物の安全性を評価する過程でジャトロファの代謝産物中に,既存の強力な発癌プロモーション活性物質であるPMAの作用を逆に抑制する作用を持つ代謝産物が存在することを示唆する結果を得た。本研究では、この抗発がんプロモーション活性物質の化学的性状および生理活性について知見を得た。\n研究成果の概要（英文）：Jatropha curcas is a tropical shrub which contains more than 50 % (w/w) liquid neutral lipid suitable for biodiesel production in its seeds and is expected as a raw crop for next generation biofuels. On the other hand, this plant produces phorbol esters having tumor promoting activity as a secondary metabolite other than lipids. In the process of evaluating the safety of this plant, we found that this plant also contains metabolites that act as the counteractant of PMA, which is known as a potent tumor promoter. In this study, we gained insights on the chemical properties and physiological activities of this anti-tumor promoting metabolite of this this plant.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2017;   課題番号：26420801;   研究分野：生物有機化学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26420801/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAJIYAMA,Shinichiro"},{"subitem_text_language":"en","subitem_text_value":"YANAGIHARA,Itaru"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部; 教授"},{"subitem_text_value":"大阪母子医療センター研究所免疫部門; 部長"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梶山, 慎一郎"},{"creatorName":"カジヤマ, シンイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"柳原, 格"},{"creatorName":"ヤナギハラ, イタル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-22"}],"displaytype":"detail","filename":"26420801seika.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26420801seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19773/files/26420801seika.pdf"},"version_id":"d2ac6199-33ac-499f-803c-f38e08548f91"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Jatropha curcas","subitem_subject_scheme":"Other"},{"subitem_subject":"phorbolester","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-tumor promoter","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"燃料作物ジャトロファの安全性評価に基づく抗発がんプロモーション活性物質の取得","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"燃料作物ジャトロファの安全性評価に基づく抗発がんプロモーション活性物質の取得"},{"subitem_title":"Development of anti-tumor-promoting reagent basad on the safety assessment of fuel crop Jatropha curcas","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-22"},"publish_date":"2018-11-22","publish_status":"0","recid":"19773","relation_version_is_last":true,"title":["燃料作物ジャトロファの安全性評価に基づく抗発がんプロモーション活性物質の取得"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:34:26.092532+00:00"}