{"created":"2023-06-20T16:47:58.239520+00:00","id":19758,"links":{},"metadata":{"_buckets":{"deposit":"ecd589ec-330c-47b0-9334-1fcfca9d2883"},"_deposit":{"created_by":3,"id":"19758","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19758"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019758","sets":["14:2667:4459"]},"author_link":["33588","33589","33590"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：脳放射線壊死組織内に集積する M2 マクロファージでは B7-H3 および B7-H5 といった免疫抑制性分子が発現亢進していることが判明した。同様にグリオーマ放射線脳壊死マウスモデルにおいても同分子の発現亢進がみられ、これらの分子が放射線脳壊死の周囲浮腫に関与していることが明らかとなった。次世代シークエンサーを用いたマウス腸内細菌叢解析の結果、クロストリジア目が脳放射線壊死に関連する免疫応答の強度と相関していた。また M2 除去実験によりマウス生存日数の著明な延長がみられた。以上より、脳放射線壊死の悪化には組織中に浸潤する M2 マクロファージおよび腸内細菌が関与していることが示唆された。\n研究成果の概要（英文）：In M2 macrophages accumulating in radioactive necrotic brain tissues, immunosuppressive molecules such as B7-H3 and B7-H5 were found to be upregulated. Likewise, in the mouse model, the expression of these molecules was also enhanced, and they were found to be involved in peripheral edema of radiation brain necrosis. Analysis of intestinal microflora in mice using the next generation sequencer showed that Clostridia correlated with the intensity of the immune response related to cerebral radiation necrosis. M2 removal experiment showed marked prolongation of mouse survival days. These results suggest that M2 macrophages and intestinal bacteria infiltrating into tissues are involved in the deterioration of cerebral radiation necrosis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2015～2017;   課題番号：15K10348;   研究分野：脳腫瘍;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10348/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"FUJITA, Mitsugu"},{"subitem_text_language":"en","subitem_text_value":"NAKATA, Susumu"},{"subitem_text_language":"en","subitem_text_value":"MIYATAKE, Shin-Ichi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"京都薬科大学薬学部; 准教授"},{"subitem_text_value":"大阪医科大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤田, 貢"},{"creatorName":"フジタ, ミツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33588","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40609997","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"中田, 晋"},{"creatorName":"ナカタ, ススム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33589","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"8059615","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"宮武, 伸一"},{"creatorName":"ミヤタケ, シンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33590","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"8059615","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K10348seika.pdf","filesize":[{"value":"649.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K10348seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19758/files/15K10348seika.pdf"},"version_id":"0b75edca-ca67-417a-bc57-2c3fcf5b1913"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"グリオーマ","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線脳壊死","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫チェックポイント分子","subitem_subject_scheme":"Other"},{"subitem_subject":"腸内細菌叢","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"グリオーマ治療後脳放射線壊死における M2 マクロファージの病的意義の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"グリオーマ治療後脳放射線壊死における M2 マクロファージの病的意義の解明"},{"subitem_title":"Impact of M2 macrophages on glioma-relevant radiation necrosis of the brain","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19758","relation_version_is_last":true,"title":["グリオーマ治療後脳放射線壊死における M2 マクロファージの病的意義の解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:34:50.559207+00:00"}