{"created":"2023-06-20T16:47:58.174782+00:00","id":19757,"links":{},"metadata":{"_buckets":{"deposit":"cb8c6645-e36b-4f75-b25e-68ce8eecb81d"},"_deposit":{"created_by":3,"id":"19757","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19757"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019757","sets":["14:2667:4459"]},"author_link":["33585","33586","33587"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：気道過敏性検査時の呼吸困難と脳皮質活動の関係を検討した。気管支喘息患者（気道過敏性陽性）13名と健常人6名を対象とし、脳皮質の活動は、光トポグラフィ装置を用いて計測した。気管支喘息患者で脳皮質の活性化と呼吸困難感とが相関がみられた。ピーク時の呼吸困難は健常者に比べて喘息患者で強かったが、脳皮質の活性化は喘息患者の方が有意に低値であった。さらに、喘息患者では、喘息の罹患期間とピーク時の脳活動とに負の相関がみられた。したがって、気管支喘息患者では呼吸困難に伴う脳皮質活動が低下しており、罹患期間に関連していることが示唆された。\n研究成果の概要（英文）：We previously reported that exertional dyspnea was related to activation(oxygenation) of the prefrontal cortex in COPD patients and control subjects. However, it is unknown which activated brain area is associated with this symptom in patients with bronchial asthma.To investigate the activation of cortical areas associated with dyspnea during methacholine bronchial provocation tests. Thirteen asthma patients and six control subjects underwent methacholine bronchial provocation tests.Cerebral hemodynamics and oxygenation were determined by near-infrared spectroscopy (NIRS). Changes from baseline recordings of cortical oxyhemoglobin (Oxy-Hb) concentrations were measured. Increased oxy-Hb (oxygenation) was assumed to reflect cortical activation. Results: Cortical activation was detected in the right prefrontal area in all subjects during their sensation of dyspnea.Prefrontal cortex activation is associated with dyspnea during methacholine bronchial provocation tests.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2017;   課題番号：26461171;   研究分野：呼吸器内科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461171/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HIGASHIMOTO, Yuji"},{"subitem_text_language":"en","subitem_text_value":"HONDA, Noritsugu"},{"subitem_text_language":"en","subitem_text_value":"TOHDA, Yuji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"公益財団法人田附興風会; その他; 研究員"},{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東本, 有司"},{"creatorName":"ヒガシモト, ユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"本田, 憲胤"},{"creatorName":"ホンダ, ノリツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"東田, 有智"},{"creatorName":"トウダ, ユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"26461171seika.pdf","filesize":[{"value":"151.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26461171seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19757/files/26461171seika.pdf"},"version_id":"48958ce9-bb4a-4864-959f-41d977b85bac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"呼吸困難感","subitem_subject_scheme":"Other"},{"subitem_subject":"気管支喘息","subitem_subject_scheme":"Other"},{"subitem_subject":"気道過敏性検査","subitem_subject_scheme":"Other"},{"subitem_subject":"脳皮質活動","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"気管支喘息における呼吸困難と脳活動に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"気管支喘息における呼吸困難と脳活動に関する研究"},{"subitem_title":"Prefrontal cortex activation is associated with dyspnea during methacholine bronchial provocation tests","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19757","relation_version_is_last":true,"title":["気管支喘息における呼吸困難と脳活動に関する研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:34:52.238664+00:00"}