{"created":"2023-06-20T16:47:57.713875+00:00","id":19750,"links":{},"metadata":{"_buckets":{"deposit":"eecfd1d4-a1a6-49cc-83aa-24af53c3bf9e"},"_deposit":{"created_by":3,"id":"19750","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19750"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019750","sets":["14:2667:4459"]},"author_link":["33565"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：近年の研究により、統合失調症とオリゴデンドロサイト（OLs）の機能異常との相関が報告されている。本研究は、OLsの分化における統合失調症関連因子DISC1の結合因子DBZの分子機構を解明することで統合失調症発症の分子機序の解明を目的とした。OLsにおけるDBZ結合因子としてモータータンパク質dyneinの補助因子である NDE1に着目した。NDE1は髄鞘形成時期にマウス脳梁OLsに発現し、OLsにおけるNDE1発現抑制やdyneinとの結合阻害によってOLsの分化レベルが低下した。以上よりDBZ-NDE1-dyneinの複合体がOLs分化に重要な働きをしている可能性が示唆された。\n研究成果の概要（英文）：Recent studies have implicated oligodendrocyte (OL) abnormalities in schizophrenia. To better elucidate the molecular mechanisms underlying the pathophysiology of schizophrenia, we investigated the function of DISC1-Binding Zinc finger protein (DBZ) in OL differentiation as DISC1 is a risk gene of schizophrenia. We examined the dynein cofactor, nuclear distribution E homolog 1 (NDE1), which binds to DBZ in OLs. Postnatally, when myelin formation is active, NDE1 mRNA is expressed in OL lineage cells in the mouse corpus callosum. An in vitro analysis revealed that NDE1 knockdown impaired OL differentiation. In addition, overexpression of the dynein-binding region of NDE1 resulted in impairments in OL differentiation like those observed following NDE1 knockdown. These results suggested that the DBZ-NDE1-dynein complex regulates OL differentiation.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2015～2017;   課題番号：15K18381;   研究分野：神経科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18381/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SHIMIZU, Shoko"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学東洋医学研究所; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 尚子"},{"creatorName":"シミズ, ショウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33565","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50572731","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K18381seika.pdf","filesize":[{"value":"183.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K18381seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19750/files/15K18381seika.pdf"},"version_id":"19eb41ac-71da-4c51-b563-b66dc716a321"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オリゴデンドロサイト","subitem_subject_scheme":"Other"},{"subitem_subject":"統合失調症","subitem_subject_scheme":"Other"},{"subitem_subject":"DISC1","subitem_subject_scheme":"Other"},{"subitem_subject":"DBZ","subitem_subject_scheme":"Other"},{"subitem_subject":"ミエリン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オリゴデンドロサイトにおける統合失調症関連因子DBZの機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オリゴデンドロサイトにおける統合失調症関連因子DBZの機能解析"},{"subitem_title":"Functional analysis of the schizophrenia-associated factor DBZ in oligodendrocytes","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19750","relation_version_is_last":true,"title":["オリゴデンドロサイトにおける統合失調症関連因子DBZの機能解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:04.155854+00:00"}