{"created":"2023-06-20T16:47:57.538740+00:00","id":19747,"links":{},"metadata":{"_buckets":{"deposit":"abb0bc6a-04df-4d40-988e-5226a1588ff7"},"_deposit":{"created_by":3,"id":"19747","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19747"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019747","sets":["14:2667:4459"]},"author_link":["33558"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：マウスに卵巣癌細胞を接種し、動物由来タンパクを20%含む餌を与えると、動物由来タンパクを10%含む餌や植物由来タンパクを20%含む餌を与えた場合に比して、腫瘍増殖速度が減少した。マウス血中のインシュリン濃度やIGF-1濃度は、動物由来タンパクを与えたマウスの方が植物由来タンパクを与えたマウスよりも高かった。腫瘍細胞におけるmTOR経路の活性をあらわすリン酸化4-EBP1の発現量を調べると、動物由来タンパクを与えたマウスの方が植物由来タンパクを与えたマウスよりも多かった。したがって、動物由来タンパクの摂取によって、腫瘍細胞におけるIGF-1/mTOR経路が活性化し、腫瘍細胞の増殖を促進させる。\n研究成果の概要（英文）：We evaluated whether different dietary protein qualities (isocaloric diets involving animal or plant protein) could inhibit the ovarian cancer growth in mice. In the mice of the 20% plant protein group, the ovarian cancer growth was reduced in comparison to the mice in the 20% animal protein group. The serum levels of insulin and IGF-1 levels were both lower in the mice of the 20% plant protein group than in the mice of the 20% animal protein group. Immunohistochemistry revealed that the level of p-4EBP1 (one of the major downstream effectors of the mTOR pathway) of the plant protein group was weaker than that of the animal protein group. Our findings suggest that a diet high in plant protein reduces the growth of human ovarian cancer cells in mice compared to a diet high in animal protein, possibly through the lack of activation of the IGF/Akt/mTOR pathway.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：挑戦的萌芽研究;  研究期間：2016～2017;   課題番号：16K15707;   研究分野：gynecological cancer;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15707/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MATSUMURA, Noriomi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松村, 謙臣"},{"creatorName":"マツムラ, ノリオミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"16K15707seika.pdf","filesize":[{"value":"241.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K15707seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19747/files/16K15707seika.pdf"},"version_id":"176bac27-e8a8-4a55-bfc6-9fe599020f92"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"卵巣癌","subitem_subject_scheme":"Other"},{"subitem_subject":"食品","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"食品の違いが卵巣がんの進展に影響を及ぼすメカニズムの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食品の違いが卵巣がんの進展に影響を及ぼすメカニズムの解析"},{"subitem_title":"Investigation of the mechanism how dietary foods influence on progression of ovarian cancer.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19747","relation_version_is_last":true,"title":["食品の違いが卵巣がんの進展に影響を及ぼすメカニズムの解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:09.661429+00:00"}