{"created":"2023-06-20T16:47:57.361171+00:00","id":19742,"links":{},"metadata":{"_buckets":{"deposit":"f3bb1668-7b51-43ee-a237-2175182d353c"},"_deposit":{"created_by":3,"id":"19742","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19742"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019742","sets":["14:2667:4459"]},"author_link":["33550","33551","33549"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：緑茶は世界で広く飲用されており、その主成分はEGCGであり、抗酸化作用を有する。今回、老齢ラット脳外傷モデルを用いてEGCG飲料による脳外傷後の脳機能の改善効果を調べた。24か月齢のwistar rats に0.1%ECGC(ECGC群)またはwater(water群)を受傷前4週より与え受傷させた。脳外傷後にwater飲料群はssDNA, 8-OHdG, 4-HNE陽性細胞及び過酸化脂質量の有意な増加認めた。EGCG飲料群でNeuN陽性細胞数で有意な増加を認めた。脳機能評価でEGCG飲料群で有意な改善効果が認められた。脳外傷後に起こる脳機能不全をEGCG飲料群は有意な改善効果をしめした。\n研究成果の概要（英文）：A major component of green tea, a widely consumed beverage, is EGCG, which has strong antioxidant properties. In this study, we investigated the effects of EGCG on cerebral function and morphology following TBI. 24-month-old rats male Wistar rats that had access to normal drinking water, or water containing 0.1% (w/v) EGCG ad libitum, received TBI with a pneumatic controlled injury device for 4weeks. Immunohistochemistry and lipid peroxidation studies revealed that at 1, 3 and 7 days post-TBI, the number of 8-OHdG-, 4-HNE- and ssDNA-positive cells, and the levels of MDA around the damaged area after TBI, significantly decreased in the EGCG treatment group compared with the water group. In addition, there was a significant increase in the number of surviving neuronal cells and an improvement in cerebral dysfunction after TBI in the EGCG treatment group compared with the water group. In summary, consumption of green tea may be an effective therapy for TBIaged patients.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2015～2017;   課題番号：15K00898;   研究分野：神経病理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K00898/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SATOU, Takao"},{"subitem_text_language":"en","subitem_text_value":"ITOH, Tatsuki"},{"subitem_text_language":"en","subitem_text_value":"INOUE, Takao"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 教授"},{"subitem_text_value":"近畿大学農学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 隆夫"},{"creatorName":"サトウ, タカオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊藤, 龍生"},{"creatorName":"イトウ, タツキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"井上, 敬夫"},{"creatorName":"イノウエ, タカオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K00898seika.pdf","filesize":[{"value":"481.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K00898seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19742/files/15K00898seika.pdf"},"version_id":"29ec08e1-bda6-46e9-9312-72fa5242b369"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"緑茶","subitem_subject_scheme":"Other"},{"subitem_subject":"高齢者","subitem_subject_scheme":"Other"},{"subitem_subject":"脳外傷","subitem_subject_scheme":"Other"},{"subitem_subject":"神経保護","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"EGCG","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"緑茶が及ぼす加齢ラット脳外傷後の脳機能改善効果及び神経再生促進効果に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"緑茶が及ぼす加齢ラット脳外傷後の脳機能改善効果及び神経再生促進効果に関する研究"},{"subitem_title":"(-)-epigallocatechin-3-gallate protects against neuronal cell death and improves cerebralfunction after traumatic brain injury in aged rats","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19742","relation_version_is_last":true,"title":["緑茶が及ぼす加齢ラット脳外傷後の脳機能改善効果及び神経再生促進効果に関する研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:15.847540+00:00"}