{"created":"2023-06-20T16:47:57.030789+00:00","id":19735,"links":{},"metadata":{"_buckets":{"deposit":"627210d6-8aad-4193-b04c-b2677c420e52"},"_deposit":{"created_by":3,"id":"19735","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19735"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019735","sets":["14:2667:4459"]},"author_link":["33532"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、マウスを用いて実験を行い、食事と運動のタイミングを人為的に調節することで、遺伝子変異により損なわれた、活動および遺伝子発現における日内リズムを補強することができた。この結果は、適切な時間帯に食事や運動負荷を与えることで、疾病や老化によって減弱した体内時計を回復できる可能性を示す。また、時計遺伝子CLOCK変異マウスの中枢体内時計では、遺伝子発現リズムのパターンが変化していることを発見し、細胞レベルでのリズム減衰がその原因であることが示唆された。CLOCK変異マウスは夜間の光暴露などの刺激によって体内時計が大きくずれることが知られており、今回の発見が、その一因である可能性を示した。\n研究成果の概要（英文）： In this research, the circadian activity rhythms and gene expression rhythms of mice with clock or clock-related gene mutation were restored by adjusting the timing of a meal and an exercise artificially. This result showed a possibility that the meal and exercise given in the suitable time zone remedies an attenuated biological clock. Moreover,we found the abnormal pattern of a gene expression rhythm in the central biological clock of the CLOCK mutant mice, and it was suggested that attenuation of rhythms on each cell caused that phenomenon. The biological clock of CLOCK mutant mice shifts greatly by light exposure at night. Our findings advance understanding of this abnormal characteristics of biological clock in the CLOCK mutant mice.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2015～2017;   課題番号：15K08221;   研究分野：時間生物学   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08221/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SUJINO, Mitsugu"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部解剖学; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"筋野, 貢"},{"creatorName":"スジノ, ミツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K08221seika.pdf","filesize":[{"value":"270.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K08221seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19735/files/15K08221seika.pdf"},"version_id":"804554ad-f804-4aca-85b8-608dea5bc667"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"体内時計","subitem_subject_scheme":"Other"},{"subitem_subject":"概日リズム","subitem_subject_scheme":"Other"},{"subitem_subject":"視交叉上核","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"末梢体内時計の人為的操作と慨日リズム機構の回復の試み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"末梢体内時計の人為的操作と慨日リズム機構の回復の試み"},{"subitem_title":"An approach to restoring attenuated circadian physiological rhythms using artificial time cue.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19735","relation_version_is_last":true,"title":["末梢体内時計の人為的操作と慨日リズム機構の回復の試み"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:26.723740+00:00"}