{"created":"2023-06-20T16:47:56.986835+00:00","id":19734,"links":{},"metadata":{"_buckets":{"deposit":"bff4f92c-51f1-4124-9a5e-741004c6fadd"},"_deposit":{"created_by":3,"id":"19734","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19734"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019734","sets":["14:2667:4459"]},"author_link":["30490","33530"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：最近、骨格筋と骨の相互関連(筋・骨連関)が注目されている。私共はマウスを用いて、力学的因子の筋・骨連関に及ぼす影響を、網羅的遺伝子解析を手がかりとして検討した。その結果、重力変化は前庭系を介して筋量や骨量に影響をおよぼすこと、その作用に筋から産生される体液性因子としてフォリスタチンが関与すること、メカニカルストレスは、筋からのアイリシン産生を介して、骨密度を増加させる報告に作用することを明らかにした。\n研究成果の概要（英文）：The interactions between skeletal muscle and bone (muscle/bone relationships) have been recently noted. We investigated the influences of mechanical factors on muscle/bone relationships using the comprehensive gene analysis in mice. Our studies indicated the following conclusions: 1. Gravity change affects muscle and bone volume through the vestibular system. 2. Follistatin is involved in the effects of gravity change on muscle and bone as a humoral factor from muscle tissues. 3. Mechanical stress increases bone mineral density through the enhancement of irisin production from muscle.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2015～2017;   課題番号：15K08220;   研究分野：環境生理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08220/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAJI, Hiroshi"},{"subitem_text_language":"en","subitem_text_value":"KAWAO, Naoyuki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梶, 博史"},{"creatorName":"カジ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33530","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90346255","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"河尾, 直之"},{"creatorName":"カワオ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30490","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70388510","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K08220seika.pdf","filesize":[{"value":"164.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K08220seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19734/files/15K08220seika.pdf"},"version_id":"aa181339-9eb3-4645-b004-6d73873cf584"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨格筋","subitem_subject_scheme":"Other"},{"subitem_subject":"骨","subitem_subject_scheme":"Other"},{"subitem_subject":"メカニカルストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"重力","subitem_subject_scheme":"Other"},{"subitem_subject":"前庭系","subitem_subject_scheme":"Other"},{"subitem_subject":"フォリスタチン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"力学的因子により誘導される筋と骨のネットワークシステム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"力学的因子により誘導される筋と骨のネットワークシステム"},{"subitem_title":"Muscle and bone network system induced by mechanical factors","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19734","relation_version_is_last":true,"title":["力学的因子により誘導される筋と骨のネットワークシステム"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:28.352246+00:00"}