{"created":"2023-06-20T16:47:56.943483+00:00","id":19733,"links":{},"metadata":{"_buckets":{"deposit":"de5fcbf0-71a4-4f16-a429-ec877cf147c7"},"_deposit":{"created_by":3,"id":"19733","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19733"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019733","sets":["14:2667:4459"]},"author_link":["33528","33529"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：従来、多発性硬化症(MS) では、IL-17 産生型ヘルパーT 細胞(Th17) は増悪に、制御性T 細胞(Tregs) は抑制に働くとされてきた。我々はMS のウイルスモデルであるタイラーウイルス誘導性脱髄疾患を用いてTh17 には1) 炎症の増悪、2) 抗ウイルス免疫の抑制、3) 神経保護作用の3 つの、またTregs には1) 炎症の抑制、2) 抗ウイルス免疫の抑制の2 つの善玉・悪玉双方の役割があることを解明した。これにより将来的にヒトMSの免疫調整治療には個々の症例のTh17・Tregsの役割に基づいて治療方針をたてるべきであることが示唆された。\n研究成果の概要（英文）：In mulitple sclerosis (MS), it has been proposed that IL-17-producing T helper (Th)17 cells are detrimental, and regulatory T cells (Tregs) are protective. Using a viral model for MS, Theiler's murine encephalomyelitits virus (TMEV)-induced demyelinating disease (TMEV-IDD), we aimed to clarify the roles of Th17 cells and Tregs. Using methods to increase the numbers of Th17 cells or Tregs (\"gain-of-function\" approach), we found that Th17 cells have three roles: 1) exacerbation of inflammation, 2) suppression of anti-viral immunity, and 3) neuroprotection and that Tregs have two roles: 1) suppression of inflammation and 2) suppression of anti-viral immunity. Therefore, Th17 cells and Tregs may play either beneficial or detrimental roles in MS, depending on the causes or disease course. These findings can be used for futuretailor-made treatment of MS, in which Th17 cells and Tregs should be modulated depending on the conditions of patients with MS.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：研究活動スタート支援;  研究期間：2016～2017;   課題番号：16H07356;   研究分野：ウイルス学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H07356/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TSUNODA, Ikuo"},{"subitem_text_language":"en","subitem_text_value":"OMURA, Seiichi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"角田, 郁生"},{"creatorName":"ツノダ, イクオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"尾村, 誠一"},{"creatorName":"オムラ, セイイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"16H07356seika.pdf","filesize":[{"value":"589.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16H07356seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19733/files/16H07356seika.pdf"},"version_id":"c465168c-2223-4496-b618-ce5bca57a31f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ウイルス","subitem_subject_scheme":"Other"},{"subitem_subject":"多発性硬化症","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫学","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"動物モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"神経ウイルス学","subitem_subject_scheme":"Other"},{"subitem_subject":"Tリンパ球","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスレーショナルリサーチ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"多発性硬化症のウイルスモデルのTh17/Treg細胞の役割は病期によって異なるか","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"多発性硬化症のウイルスモデルのTh17/Treg細胞の役割は病期によって異なるか"},{"subitem_title":"Does the role of Th17/Treg cells differ depending on the disease stage?","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19733","relation_version_is_last":true,"title":["多発性硬化症のウイルスモデルのTh17/Treg細胞の役割は病期によって異なるか"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:30.421923+00:00"}