{"created":"2023-06-20T16:47:56.722312+00:00","id":19728,"links":{},"metadata":{"_buckets":{"deposit":"3775b346-d716-4fbd-af65-df5e261df634"},"_deposit":{"created_by":3,"id":"19728","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19728"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019728","sets":["14:2667:4459"]},"author_link":["33513","33510","33511","33512"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、アストロサイトに豊富に存在するDISC1がアストロサイトの増殖、移動、分化、オリゴデンドロサイトとのクロストークあるいは脳傷害時の反応性アストロサイトへの分化などに関与するか否かを明らかにすることで、DISC1機能障害を基盤とする統合失調症の発症機構を確立し、ニューロン－アストロサイト－オリゴデンドロサイトの発達ネットワークの破綻としての統合失調症の病態解明に多大な寄与を果たすことを目的とした。機能解析結果からは明確な役割を同定するには至らなかったが、免疫組織化学的な検討から、線維型アストロサイトおよび放射状アストロサイトでのDISC1の十分な発現を見出すことが出来た。\n研究成果の概要（英文）：The major psychiatric disorders such as schizophrenia are thought to be multifactorial diseases related to both genetic and environmental factors. However, the genes responsible and the molecular mechanisms underlying the pathogenesis of schizophrenia remain unclear. We previously reported that abnormalities of disrupted-in-Schizophrenia-1 (DISC1) might cause major psychiatric disorders such as schizophrenia. In our previous study, we observed that DISC1 expression detected in primary astrocytes cultures.In this study, we further identified that DISC1 expressions were observed in both fibrillary astrocyte and radial astrocyte in the mice brain. Our data suggest that DISC1 in astrocyte might be possibly related to schizophrenia.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2015～2017;   課題番号：15K06790;   研究分野：神経化学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06790/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TOHYAMA, Masaya"},{"subitem_text_language":"en","subitem_text_value":"TANAKA, Takashi"},{"subitem_text_language":"en","subitem_text_value":"SHIMIZU, Shoko"},{"subitem_text_language":"en","subitem_text_value":"MIYATA, Shingo"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学東洋医学研究所; 教授"},{"subitem_text_value":"近畿大学付置研究所; 助教"},{"subitem_text_value":"近畿大学東洋医学研究所; 助教"},{"subitem_text_value":"近畿大学東洋医学研究所; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"遠山, 正彌"},{"creatorName":"トウヤマ, マサヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33510","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40028593","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"田中, 貴士"},{"creatorName":"タナカ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33511","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30734694","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"清水, 尚子"},{"creatorName":"シミズ, ショウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33512","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50572731","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"宮田, 信吾"},{"creatorName":"ミヤタ, シンゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33513","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70403194","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K06790seika.pdf","filesize":[{"value":"179.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K06790seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19728/files/15K06790seika.pdf"},"version_id":"1d35ad80-eb88-40c1-9f50-0219463b89e3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DISC1","subitem_subject_scheme":"Other"},{"subitem_subject":"アストロサイト","subitem_subject_scheme":"Other"},{"subitem_subject":"統合失調症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アストロサイトに高発現するDISC1の機能解析～統合失調症との関連を中心に～","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アストロサイトに高発現するDISC1の機能解析～統合失調症との関連を中心に～"},{"subitem_title":"Molecular mechanisms of the DISC1 functions in astrocyte-a study that is focused on the relationship with schizophrenia-","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19728","relation_version_is_last":true,"title":["アストロサイトに高発現するDISC1の機能解析～統合失調症との関連を中心に～"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:38.814704+00:00"}