{"created":"2023-06-20T16:47:56.633199+00:00","id":19726,"links":{},"metadata":{"_buckets":{"deposit":"59a578be-e6b5-408a-b675-51ef7ea4dd53"},"_deposit":{"created_by":3,"id":"19726","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19726"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019726","sets":["14:2667:4459"]},"author_link":["33505","33507","33506"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：過去の動物実験ではオステオカルシン(OC)欠乏は耐糖能異常を発症させ、OCの添加がそれを正常化し、人の断面研究でも血清OC値と血糖指標との間に負の相関が認められている。本研究では血清OC値と糖尿病発症との関連を前向きに検討した。その結果、血清OC値の１SD上昇当たり10%程度の糖尿病発症リスクの減少が見られた。しかし、統計的に有意には至らなかった。統計的パワーが不足しており、今後より大きな規模での検討が必要と考えられた。\n研究成果の概要（英文）：Impaired glucose tolerance was observed in osteocalcin(OC)-deficient mice and was prevented by administration of osteocalcin to the animal. Inversed association between serum OC levels and glycemic indices were reported from cross-sectional studies of humans. We investigated the relationship of serum OC levels to subsequent risk of developing diabetes mellitus (DM). We observed decreased risk of DM by 10% per 1 SD increase in OC levels at baseline, but this decrease in risk was not statistically significant. The statistical power was not sufficient to find this small change in risk to be significant in this study. Studies in a larger scale would be necessary.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：挑戦的萌芽研究;  研究期間：2016～2017;   課題番号：16K15360;   研究分野：疫学、公衆衛生学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15360/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"IKI, Masayuki"},{"subitem_text_language":"en","subitem_text_value":"TAMAKI, Junko"},{"subitem_text_language":"en","subitem_text_value":"YURA, Akiko"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"大阪医科大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊木, 雅之"},{"creatorName":"イキ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"玉置, 淳子"},{"creatorName":"タマキ, ジュンコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"由良, 晶子"},{"creatorName":"ユラ, アキコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"16K15360seika.pdf","filesize":[{"value":"226.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K15360seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19726/files/16K15360seika.pdf"},"version_id":"82427339-eeef-4bb0-b634-971d9655d525"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オステオカルシン","subitem_subject_scheme":"Other"},{"subitem_subject":"低カルボキシル化オステオカルシン","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"コホート研究","subitem_subject_scheme":"Other"},{"subitem_subject":"リスク予測","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨形成指標のオステオカルシンで糖尿病の発症を予測できるか　大規模コホート研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨形成指標のオステオカルシンで糖尿病の発症を予測できるか　大規模コホート研究"},{"subitem_title":"Does osteocalcin, a bone formation marker, predict future development of diabetes mellitus? A large-scale cohort study","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19726","relation_version_is_last":true,"title":["骨形成指標のオステオカルシンで糖尿病の発症を予測できるか　大規模コホート研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:42.262890+00:00"}