{"created":"2023-06-20T16:47:54.848161+00:00","id":19690,"links":{},"metadata":{"_buckets":{"deposit":"6787596c-3831-4534-aa76-98a32b3bdcca"},"_deposit":{"created_by":3,"id":"19690","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19690"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019690","sets":["14:2667:4459"]},"author_link":["33430","33429"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本課題は，肥満の形成過程などにおいて観察される高インスリン血症を改善することで過度の肥満，種々生活習慣病の発症を抑制する物質を探索することを目的とする．本研究の成果は，生薬コウズクより得たフェニルプロパノイド成分，生薬センキュウより得たフタリド成分，およびブラジル生薬である Carapa guianensis より得たリモノイド成分の一部が肝細胞中の中性脂肪含量を有意に低下させることを見いだした．さらにマウスを用いた in vivo での評価では，コウズクから得たフェニルプロパノイドの3日間の投与により，糖負荷時の耐糖能の改善，肝臓中中性脂肪含量の有意な低下が観察されることを明らかにした．\n研究成果の概要（英文）：The aim of this study is to find the compounds that improve hyperinsulinemia from medicinal foods. In results of this study, we found phenylpropanoids from fruit of Alpinia galanga, phthalides from rhizomes of Cnidium officinale, and limonoids from seed oil of Carapa guianensis as bioactive constituents. Reduction of triglyceride contents in HepG2 cells was observed by addition of these compounds in culture medium. Furthermore, only three times administration of phenylpropanoids, 1'S1-acetoxychavicol acetate and 1'S1-acetoxyeugenol acetate isolated from A. galanga, ameliorated glucose tolerance in mice. Additionaly, triglyceride contents in liver was reduced by the administration in mice.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2015～2017;   課題番号：15K08009;   研究分野：食品薬学，生薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08009/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NINOMIYA, Kiyofumi"},{"subitem_text_language":"en","subitem_text_value":"MORIKAWA, Toshio"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学総合研究所; 准教授"},{"subitem_text_value":"近畿大学薬学総合研究所; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"二宮, 清文"},{"creatorName":"ニノミヤ, キヨフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森川, 敏生"},{"creatorName":"モリカワ, トシオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K08009seika.pdf","filesize":[{"value":"105.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K08009seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19690/files/15K08009seika.pdf"},"version_id":"2ed581c9-2502-49b8-bccc-ad7fef3c37a7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"インスリン","subitem_subject_scheme":"Other"},{"subitem_subject":"コウズク","subitem_subject_scheme":"Other"},{"subitem_subject":"phenylpropanoid","subitem_subject_scheme":"Other"},{"subitem_subject":"センキュウ","subitem_subject_scheme":"Other"},{"subitem_subject":"phthalide","subitem_subject_scheme":"Other"},{"subitem_subject":"Carapa guianensis","subitem_subject_scheme":"Other"},{"subitem_subject":"limonoid","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"薬用食品から高インスリン血症の改善を機序とする生活習慣病改善作用成分の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬用食品から高インスリン血症の改善を機序とする生活習慣病改善作用成分の探索"},{"subitem_title":"Search for anti-lifestyle disease principles through the improvement of hyperinsulinemia from medicinal foods","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19690","relation_version_is_last":true,"title":["薬用食品から高インスリン血症の改善を機序とする生活習慣病改善作用成分の探索"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:35:58.810557+00:00"}