{"created":"2023-06-20T16:47:54.784355+00:00","id":19689,"links":{},"metadata":{"_buckets":{"deposit":"f44d2d20-39b1-417e-9537-7fddc1710c9a"},"_deposit":{"created_by":3,"id":"19689","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19689"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019689","sets":["14:2667:4459"]},"author_link":["33427","33428"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：世界各地の伝承・伝統薬物資源から潰瘍性大腸炎やクローン病などの炎症性腸疾患の治療に有用な医薬シーズを探索することを目的とする．すなわち，炎症性腸疾患の活動期において観察されるTNF-αの過剰産生により惹起される各種臓器障害や炎症反応などの種々の生体内イベントを軽減あるいは調節できる天然由来低分子化合物を探索するとともに，その活性発現の必須構造や構造活性相関を明らかにする．加えて，その病変部に顕著な増加が認められているマクロファージや好中球などのiNOS陽性細胞の活性化抑制作用およびその作用機序解明研究を実施し，もって新たな難治性炎症性疾患治療薬シーズを発見，提案することを目的とする．\n研究成果の概要（英文）：To explore new therapeutic candidates for aimed to overcoming of inflammatory bowel diseases from traditional natural resources worldwide, we searched for active constituents that regulate several inflammation reactions caused by over productions of NO and TNF-alfa etc in iNOS-positive cells. As the results, several constituents from the natural resources were investigated as the promissing candidates and their structural requirements and the mode of action were suggested.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2015～2017;   課題番号：15K08008;   研究分野：生薬・天然物化学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08008/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MORIKAWA, Toshio"},{"subitem_text_language":"en","subitem_text_value":"NINOMIYA, Kiyofumi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学総合研究所; 教授"},{"subitem_text_value":"近畿大学薬学総合研究所; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森川, 敏生"},{"creatorName":"モリカワ, トシオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"二宮, 清文"},{"creatorName":"ニノミヤ, キヨフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K08008seika.pdf","filesize":[{"value":"385.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K08008seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19689/files/15K08008seika.pdf"},"version_id":"cd1d0232-6a8e-47b1-a279-730050014112"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"難治性炎症性疾患治療薬シーズ","subitem_subject_scheme":"Other"},{"subitem_subject":"伝承・伝統薬物資源探索　一酸化窒素","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"iNOS","subitem_subject_scheme":"Other"},{"subitem_subject":"Carapa guianensis","subitem_subject_scheme":"Other"},{"subitem_subject":"Myristica fragrans","subitem_subject_scheme":"Other"},{"subitem_subject":"Shorea roxburghii","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症性腸疾患の克服をめざした新規治療薬シーズの探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症性腸疾患の克服をめざした新規治療薬シーズの探索"},{"subitem_title":"Search for new therapeutic candidates for aimed to overcoming of inflammatory bowel diseases","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19689","relation_version_is_last":true,"title":["炎症性腸疾患の克服をめざした新規治療薬シーズの探索"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:36:00.680926+00:00"}