{"created":"2023-06-20T16:47:54.589678+00:00","id":19686,"links":{},"metadata":{"_buckets":{"deposit":"64fe3210-15ba-43f7-a350-6bac6a0948f4"},"_deposit":{"created_by":3,"id":"19686","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19686"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019686","sets":["14:2667:4459"]},"author_link":["33424"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：様々な疾患の発生や進行に関わっている炎症は，薬物の体内動態にも影響することが知られている。トランスポーターは薬物の体内動態を決定する因子のひとつであり，その膜局在および機能発現には裏打ちタンパク質が重要な役割を果たしていることが明らかにされている。本課題では，炎症時のERMタンパク質リン酸化状態およびトランスポーター機能に対する炎症因子の影響について検討を行った。今回得られた結果より，一部の炎症性サイトカインがradixinのリン酸化状態を変動し，裏打ちタンパク質としての機能を調整しトランスポーターの膜局在に影響していることが明らかとなった。\n研究成果の概要（英文）：Inflammation affects pharmacokinetics of various drugs via alterations of metabolic enzymes and transporters expression. Plasma membrane localization of transporters such as P-glycoprotein and MRPs are regulated by scaffold proteins such as ERM proteins (ezrin/radixin/moesin). However, the effects of inflammation on the phosphorylation of ERM proteins and transporter activities remain unclear. Thise study demonstrated that some inflammatory factors decrease the ratios of phosphorylated radixin in liver.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2016～2017;   課題番号：16K18966;   研究分野：薬物動態学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18966/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAWASE, Atsushi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川瀬, 篤史"},{"creatorName":"カワセ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33424","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80411578","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"16K18966seika.pdf","filesize":[{"value":"110.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K18966seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19686/files/16K18966seika.pdf"},"version_id":"42709e25-06ae-4032-847a-edabd15f19f2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"トランスポーター","subitem_subject_scheme":"Other"},{"subitem_subject":"裏打ちタンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ＥＲＭタンパク質リン酸化状態およびトランスポーター機能に対する炎症因子の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ＥＲＭタンパク質リン酸化状態およびトランスポーター機能に対する炎症因子の影響"},{"subitem_title":"Effects of inflammatory factors on ERM proteins and transporters functions","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19686","relation_version_is_last":true,"title":["ＥＲＭタンパク質リン酸化状態およびトランスポーター機能に対する炎症因子の影響"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:36:05.990243+00:00"}