{"created":"2023-06-20T16:47:54.333493+00:00","id":19682,"links":{},"metadata":{"_buckets":{"deposit":"5bfe5e06-b260-46ae-abc5-404d05f9feae"},"_deposit":{"created_by":3,"id":"19682","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19682"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00019682","sets":["14:2667:4459"]},"author_link":["33417"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2017)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：Lumicanは糖鎖修飾されることが知られているが、産生される臓器や細胞により異なる糖鎖修飾を受けることが示唆されている。今回、膵臓癌細胞でのみ産生される特異糖鎖修飾を受けたlumicanの存在について検討するため、消化器癌細胞より産生されるlumicanの精製を試みた。その結果、食道癌と膵臓癌細胞から産生・分泌されるlumicanを精製することができた。また、そのlumicanの発現パターンの違いを検討した所、膵臓癌細胞特異的と思われるlumicanが発現していた。このことから、この膵臓特異的に発現するlumicanを標的とした新たな診断法の開発につながる可能性が考えられた。\n研究成果の概要（英文）：It has been suggested that there are organ or tissue specific lumican based on different glycosylation. In this study, we performed purification of lumican that is produced by gastrointestinal cancer cells using transfection of lumican expression vector to investigate whether there is a specific glycosylated lumican that is produced by pancreatic cancer cells. We successfully purified the lumican that was produced by esophageal and pancreatic cancer cells. Then, we examined the difference in expression pattern of these lumican, and found differentially expressed lumican that was considered pancreatic cancer cell specific. Thus, this lumican might be a novel target for development of diagnostic method for pancreatic cancer.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2015～2017;   課題番号：15K09054;   研究分野：消化器内科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09054/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YAMAMOTO, Tetsushi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 哲志"},{"creatorName":"ヤマモト, テツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33417","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20453920","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-20"}],"displaytype":"detail","filename":"15K09054seika.pdf","filesize":[{"value":"90.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K09054seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/19682/files/15K09054seika.pdf"},"version_id":"97fb60a9-f7a2-4cc3-a805-423aef012b64"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ルミカン","subitem_subject_scheme":"Other"},{"subitem_subject":"膵臓癌","subitem_subject_scheme":"Other"},{"subitem_subject":"糖鎖修飾","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオグリカン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膵臓癌細胞特異糖鎖修飾ルミカンを標的とした新規膵癌早期発見法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膵臓癌細胞特異糖鎖修飾ルミカンを標的とした新規膵癌早期発見法の開発"},{"subitem_title":"Development of novel early diagnostic method targeted specific glycosylated lumican in pancreatic cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4459"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-20"},"publish_date":"2018-11-20","publish_status":"0","recid":"19682","relation_version_is_last":true,"title":["膵臓癌細胞特異糖鎖修飾ルミカンを標的とした新規膵癌早期発見法の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:36:12.819011+00:00"}