| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2017-11-02 |
| タイトル |
|
|
タイトル |
<Originals> Glycemic variability and insufficient lipid control as predictors for mid-term progression of coronary atherosclerosis in patients with early diabetes: Analysis with serial continuous glucose monitoring |
|
言語 |
en |
| 著者 |
Fujita, Kosuke
Iwanaga, Yoshitaka
Ueno, Masafumi
Ikeda, Tomoyuki
Miyazaki, Shunichi
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
coronary artery disease, early diabetes, glycemic variability, HDL cholesterol, LDL cholesterol |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 所属 |
|
|
値 |
Division of Cardiology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Division of Cardiology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Division of Cardiology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Division of Cardiology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Division of Cardiology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 版 |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
|
|
出版者 |
Kindai University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 42,
号 1,
p. 1-11,
発行日 2017-06
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Background: The incidence of coronary events is higher in patients with diabetes, even after statin therapy. Recently, glycemic variability assessed by continuous glucose monitoring (CGM)has been suggested to be associated with the progression of coronary atherosclerosis in these patients. Therefore, we prospectively followed patients using serial CGM and coronary angiography(CAG)over 10 months. Methods and Results: This was a prospective observational study of 27 patients with coronary artery disease(CAD)and early stage diabetes (including impaired glucose tolerance). The progression of coronary artery percent stenosis by CAG was observed in 12 patients(the progression group). Assessment of baseline characteristics indicated that a higher mean amplitude of glycemic excursion (MAGE),an index of glycemic variability, was associated with disease progression (P＝0.023). Although low-density lipoprotein cholesterol(LDL-C) levels were significantly decreased during the 10 months, the progression group showed higher LDL-C at follow-up(P＝0.037).In addition, only patients without progression showed increased high-density lipoprotein cholesterol(HDL-C)during the 10 months. Consequently, a high LDL-C/HDLC ratio at follow-up was associated with progression(P＝0.012). However, these were not associated with changes in plaque burden or necrotic core volume on virtual histology-intravascular ultrasound. Conclusions: In Japanese patients with CAD and early stage diabetes receiving statin therapy, both glycemic variability (MAGE) at baseline and a high LDL-C/HDL-C ratio at follow-up were predictors for mid-term progression of coronary atherosclerosis. The strategies for modifying these predictors, and the effects on the progression of coronary atherosclerosis need to be explored further. |
AA0050842X-20170600-0001.pdf (589.0 kB)
