{"created":"2023-06-20T16:47:14.873538+00:00","id":18889,"links":{},"metadata":{"_buckets":{"deposit":"9b03fe4c-3a42-4657-b6c4-4f51460d9944"},"_deposit":{"created_by":3,"id":"18889","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18889"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018889","sets":["14:2667:4374"]},"author_link":["32003","32002"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：幹細胞の指標の一つであるside population (SP)細胞をつくり出す責任分子ABCトランスポーター・Bcrp1 (ABCG2)がES細胞における酸化ストレス応答で果たす役割について検討した。その結果、(1)ES細胞特異的なBcrp1 mRNAアイソフォームの転写活性化因子、(2)ES細胞でのBcrp1発現によるSP細胞亜集団の生成、(3)酸化ストレスに対するBcrp1の発現誘導と未分化維持、(4)3D-FISHによる初期胚とES細胞における核内クロマチン構造の視覚化などについて新たな知見が得られた。\n研究成果の概要（英文）：ABC transporter, Bcrp1, defines the side population (SP) cell phenotype and seems presumptive functional regulator of stem cells. This study examined the function of Bcrp1 on the oxidative stress response of mouse ES cells. The results are summarized as follows: (1) transcriptional activator of Bcrp1 mRNA isoform specific to ES cells, (2) generation of SP cell subpopulation induced by Bcrp1 expression in ES cells, (3) induction of Bcrp1 expression and maintenance of pluripotent status by the oxidative stress response, and (4) visualization of the spatial arrangement of nuclear organization using 3D-FISH in early mouse embryos and ES cells.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26450460;   研究分野：農学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26450460/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MITANI, Tasuku"},{"subitem_text_language":"en","subitem_text_value":"HARATA, Masahiko"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学先端技術総合研究所; 教授"},{"subitem_text_value":"東北大学大学院農学研究科; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三谷, 匡"},{"creatorName":"ミタニ, タスク","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"原田, 昌彦"},{"creatorName":"ハラタ, マサヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26450460seika.pdf","filesize":[{"value":"230.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26450460seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18889/files/26450460seika.pdf"},"version_id":"0024e426-c50e-41e0-a39d-ecd1b783a5cf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ES細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ABCトランスポーター","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マウスＥＳ細胞の酸化ストレス応答におけるＡＢＣトランスポーター・Ｂｃｒｐ１の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウスＥＳ細胞の酸化ストレス応答におけるＡＢＣトランスポーター・Ｂｃｒｐ１の役割"},{"subitem_title":"Molecular mechanisms of ABC transporter, Bcrp1, in the oxidative stress response in mouse embryonic stem cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18889","relation_version_is_last":true,"title":["マウスＥＳ細胞の酸化ストレス応答におけるＡＢＣトランスポーター・Ｂｃｒｐ１の役割"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:51:24.440313+00:00"}