{"created":"2023-06-20T16:47:14.599668+00:00","id":18885,"links":{},"metadata":{"_buckets":{"deposit":"4fcd637b-3308-46f8-bdfb-f6eb56307d40"},"_deposit":{"created_by":3,"id":"18885","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18885"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018885","sets":["14:2667:4374"]},"author_link":["31981","31982","31980"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、哺乳動物受精卵のエピジェネティク・リプログラムに対するユビキチン－プロテアソーム分解系（UPS）的に生殖細胞に終末分化した卵細胞から受精によって分化全能性を持つ受精卵が形成されるエピジェネティク・リプログラムの分子制御機構に関する知見を獲得した。その結果、UPSに依存した母性タンパク質の分解によって卵母細胞中の転写因子の機能が抑制される分子機序が受精によって受精卵が全能性を持つ細胞になる母性-胚性移行期に機能している可能性が示唆された。\n研究成果の概要（英文）：During the maternal-to-zygotic transition (MZT), maternal mRNAs and proteins are degraded and numerous genes are zygotically activated. We have previously shown that the transient inhibition of ubiquitin-proteasome system (UPS) after fertilization leads to a delay in the initiation of zygotic transcription and impaired full-term development in mouse. These results suggest that the degradation of maternal proteins by UPS during MZT is crucial for developmental reprogramming. However, the maternal proteins, which are degraded by UPS during MZT and can contribute to the zygotic transcription and normal development, have not been identified. In this study, we identified such maternal proteins, which is involved in the SUMO modification, and screened several candidates by examining the effects of their overexpression on preimplantation development of mouse embryos. These results suggests that a nuclear SUMO ligase is a candidate as maternal proteins degraded by UPS during MZT.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(B);  研究期間：2013～2016;   課題番号：25292189;   研究分野：分子発生生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25292189/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MATSUMOTO, Kazuya"},{"subitem_text_language":"en","subitem_text_value":"MITANI,Tasuku"},{"subitem_text_language":"en","subitem_text_value":"AMANO, Tomoko"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部; 教授"},{"subitem_text_value":"近畿大学先端技術総合研究所; 教授"},{"subitem_text_value":"近畿大学生物理工学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本, 和也"},{"creatorName":"マツモト, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"三谷, 匡"},{"creatorName":"ミタニ, タスク","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"天野, 朋子"},{"creatorName":"アマノ, トモコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"25292189seika.pdf","filesize":[{"value":"100.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25292189seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18885/files/25292189seika.pdf"},"version_id":"63b0c90b-d12d-45e6-9f05-9fec7fc76aaf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"分化全能性","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテアソーム分解系","subitem_subject_scheme":"Other"},{"subitem_subject":"受精卵","subitem_subject_scheme":"Other"},{"subitem_subject":"母性タンパク質","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"受精卵のエピジェネティク・リプログラミングへのプロテアソーム分解系の関与機構解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"受精卵のエピジェネティク・リプログラミングへのプロテアソーム分解系の関与機構解明"},{"subitem_title":"Molecular mechanisms of involvement of UPS during the maternal-to-zygotic transition","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18885","relation_version_is_last":true,"title":["受精卵のエピジェネティク・リプログラミングへのプロテアソーム分解系の関与機構解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:51:32.920850+00:00"}