{"created":"2023-06-20T16:47:14.498809+00:00","id":18883,"links":{},"metadata":{"_buckets":{"deposit":"90c897d6-c948-4aaf-85d0-0d25a6b0f0c1"},"_deposit":{"created_by":3,"id":"18883","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18883"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018883","sets":["14:2667:4374"]},"author_link":["31976"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：近年、生殖医療や家畜繁殖の分野では不妊が大きな問題になっている。その原因として、高齢化や環境ストレスによる初期胚の質低下が想定されている。「質低下」の実体は主に胚の染色体異常であることが近年の研究からわかってきた。妊娠率を向上させるためには、初期胚の染色体正常性を確実に評価する技術開発が急務である。本研究では、申請者が開発を行ってきた「初期胚ライブセルイメージング技術」を応用し、染色体正常性について定量的かつ科学的根拠を持って評価できる技術へと発展させた。\n研究成果の概要（英文）：Infertility is now a major human issue worldwide and one-sixth of couples use infertility clinics in Japan. Although more than 1 in 30 babies have now been born using assisted reproductive technologies (ARTs) such as in vitro fertilization, unfortunately, the success rates of ARTs have reduced gradually to about 10 to 20%. One of the main reasons of the poor quality of oocytes and early embryos is chromosome abnormality, most probably caused by advanced maternal age and environmental stresses. Therefore, to increase the pregnancy rate and ensure safe births, assessing embryo quality, particularly focusing on chromosome integrity, before implantation is essential. In this study, we have developed a live-cell imaging methodology that enables us to quantify various events taking place continuously from fertilization to the blastocyst stage, including chromosome segregation during cleavages in various mammalian embryos.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(A);  研究期間：2013～2016;   課題番号：25712035;   研究分野：発生工学、生殖生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25712035/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YAMAGATA, Kazuo"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山縣, 一夫"},{"creatorName":"ヤマガタ, カズオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"31976","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10361312","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"25712035seika.pdf","filesize":[{"value":"489.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25712035seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18883/files/25712035seika.pdf"},"version_id":"1572f469-d6f4-4be1-b10e-30a6422967bd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"初期胚","subitem_subject_scheme":"Other"},{"subitem_subject":"胚の質","subitem_subject_scheme":"Other"},{"subitem_subject":"ライブセルイメージング","subitem_subject_scheme":"Other"},{"subitem_subject":"定量解析","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"医学・農学的高度利用を目指した定量的初期胚評価法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"医学・農学的高度利用を目指した定量的初期胚評価法の確立"},{"subitem_title":"Quantification of embryo quality towards to medical and agricultural appications","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18883","relation_version_is_last":true,"title":["医学・農学的高度利用を目指した定量的初期胚評価法の確立"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:51:36.508665+00:00"}