{"created":"2023-06-20T16:47:14.199423+00:00","id":18876,"links":{},"metadata":{"_buckets":{"deposit":"77af7936-a405-4a8d-93dc-cc9cd0484cb8"},"_deposit":{"created_by":3,"id":"18876","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18876"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018876","sets":["14:2667:4374"]},"author_link":["31966"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：アナンダマイド（ANA)は細胞外に放出された後、再び細胞内に取り込まれ、脂肪酸アミド加水分解酵素（FAAH)によってアラキドン酸とエタノールアミンに加水分解される。ANAの過剰蓄積を防止しるためにこの代謝酵素が重要である。SOFAスコアやANAは入院後に治療の影響を受けるため治療経過においては敗血症の状態を正確に反映することはできないと考えられた。FAAHによって加水分解され放出されるアラキドン酸カスケードは特異的な所見を認めなかった。リノレン酸に関しては入院時に上昇しているものは予後が悪い結果であった。FAAHとリノレン酸系が敗血症の状態を反映するマーカーとなる可能性が考えられた。\n研究成果の概要（英文）：Anandamaide (ANA) is released from the cell extracellularly, taken into the cell again, and is hydrolyzed to arachidonic acid and ethanolamine by fatty acid amide hydrolase (FAAH). This metabolic enzyme of ANA is important to prevent overaccumulation of the ANA.Since Sequential organ failure assessment (SOFA) score and anandamaide are influenced by treatment such as Continuous hemodiafiltration (CHDF) after admisssion, it seems that it is not possible to reflect the condition of sepsis accurately in the course of treatment by SOFA and anandamide. The arachidonic acid cascade hydrolyzed and released by FAAH did not show any specific findings. When linolenic acid was increased at the time of admission, it was a result of poor prognosis. It seems that FAAH and linolenic acid system may be useful markers reflecting the condition of sepsis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2015～2016;   課題番号：15K20353;   研究分野：救急医学, 集中治療医学、敗血症、感染症;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K20353/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HAMAGUCHI, Mitsuhide"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"濱口, 満英"},{"creatorName":"ハマグチ, ミツヒデ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"31966","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10550866","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"15K20353seika.pdf","filesize":[{"value":"158.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K20353seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18876/files/15K20353seika.pdf"},"version_id":"689458b9-e99c-42e7-93dc-a263c0223106"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"敗血症","subitem_subject_scheme":"Other"},{"subitem_subject":"FAAH","subitem_subject_scheme":"Other"},{"subitem_subject":"アナンダマイド","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"敗血症性ショックにおける早期診断マーカーの研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"敗血症性ショックにおける早期診断マーカーの研究"},{"subitem_title":"Research of early diagnostic markers in septic shock","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18876","relation_version_is_last":true,"title":["敗血症性ショックにおける早期診断マーカーの研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:50:58.150873+00:00"}