{"created":"2023-06-20T16:47:14.154017+00:00","id":18875,"links":{},"metadata":{"_buckets":{"deposit":"5543fdd3-7c86-40e5-9917-dcdea86aaacd"},"_deposit":{"created_by":3,"id":"18875","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18875"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018875","sets":["14:2667:4374"]},"author_link":["31964","31963","31965"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：プロテアソームの機能を制御するガンキリンは大腸前癌病変において発現が亢進し、大腸発癌に重要な役割を果たしている。これまでガンキリンの機能解析は主に細胞株で行われてきたが、実際の生体では、上皮細胞、間質細胞、幹細胞の細胞間の相互作用が発癌を決定する。本研究ではガンキリンを大腸上皮細胞、炎症細胞、又は幹細胞で欠損させたknock-out mouseを用いて、生体での機能解析を行い、炎症細胞でのガンキリンがSTAT3, ERK, 幹細胞の増幅を制御して大腸癌の発生および治療抵抗性に関わっていることがわかった。ガンキリンは新しい治療およびバイオマーカーの標的分子として有望である。\n研究成果の概要（英文）：We analyzed gene expression of colon tissues obtained from 354 patients with IBD and CAC and found that expression of gankyrin was much higher in colonic mucosa of patients with refractory IBD than in those with IBD in remission. Expression of gankyrin was upregulated in inflammatory cells as well as tumor cells in colonic mucosa of patients with CAC. The interaction between ganlyrin and SHP-1 leads to inhibition of STAT3 activation and to enhancement of TNF-alpha and IL-17 in inflammatory cells. We created mice with intestinal epithelial cell-specific gankyrin ablation and deletion of gankyrin in myeloid and epithelial cells. Gankyrin deficiency in myeloid cells reduced the activity of ERK and the expression of stem cell markers, leading to attenuated tumorigenic potential. These findings provide important insights into the pathogenesis of CAC and suggest that gankyrin is a promising target for developing therapeutic and preventive strategies against CAC.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26460979;   研究分野：消化器内科;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460979/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SAKURAI, Toshiharu"},{"subitem_text_language":"en","subitem_text_value":"KUDO, Masatoshi"},{"subitem_text_language":"en","subitem_text_value":"FUJITA, Jun"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"京都大学医学研究科; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"櫻井, 俊治"},{"creatorName":"サクライ, トシハル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"工藤, 正俊"},{"creatorName":"クドウ, マサトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"藤田, 潤"},{"creatorName":"フジタ, ジュン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26460979seika.pdf","filesize":[{"value":"106.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26460979seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18875/files/26460979seika.pdf"},"version_id":"8913c715-eedc-4a51-b7a6-6793832fbf38"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性腸疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス応答","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌、炎症性腸疾患における新規治療標的分子およびバイオマーカーの探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌、炎症性腸疾患における新規治療標的分子およびバイオマーカーの探索"},{"subitem_title":"Novel molecular target in colorectal cancer and inflammatory bowel disease","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18875","relation_version_is_last":true,"title":["大腸癌、炎症性腸疾患における新規治療標的分子およびバイオマーカーの探索"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:46:20.134542+00:00"}