{"created":"2023-06-20T16:47:14.058547+00:00","id":18873,"links":{},"metadata":{"_buckets":{"deposit":"aa797977-05b6-4829-93e0-0c434fb14312"},"_deposit":{"created_by":3,"id":"18873","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18873"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018873","sets":["14:2667:4374"]},"author_link":["31959"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：糸球体単離灌流実験では、糸球体血行動態調節機構に及ぼす加齢の影響を検討したが、有意な成果は得られなかった。また、糸球体血行動態調節機構の分子生物学的機序を明らかにする目的で、輸出入細動脈の血管平滑筋細胞と血管内皮細胞の培養系確立を目指したが、確立するに至らなかった。腎内小胞体ストレスに関する検討では、悪性腎硬化症の腎臓では酸化ストレスを含む種々のストレスが増強しているにも関わらずオートファジーが減弱しており、腎障害に寄与している可能性を示唆する成果が得られた。また、降圧薬治療による腎障害の抑制にはマクロオートファジーやシャペロン介在性オートファジーの活性化が関与する可能性が示唆された。\n研究成果の概要（英文）： Using malignant hypertension model rats (M-SHRSP) we found that activations of endoplasmic reticulum stress (ERS) and apoptotic pathway but not autophagy are involved in the pathophysiology of hypertensive renal damage. We also found that antihypertensive therapy improve renal damage by downregulating ERS pathway, though it upregulats autophagy pathways. These findings raise a possibility that ERS and autophagy could be a new therapeutic target for hypertensive renal disease, especially malignant nephrosclerosis. On the other hand, we could not obtain any successful results in the series of physiological study. We found neither age-related alterations in the control of glomerular hemodynamics nor in the vascular reactivity of renal arterioles. In addition, we could not establish a culture system of vascular smooth muscle cells and endothelial cells of renal arterioles to study their detail cellular mechanisms.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：挑戦的萌芽研究;  研究期間：2014～2016;   課題番号：26670434;   研究分野：医歯薬学, 腎臓内科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670434/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ARIMA, Shuji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"有馬, 秀二"},{"creatorName":"アリマ, シュウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26670434seika.pdf","filesize":[{"value":"93.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26670434seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18873/files/26670434seika.pdf"},"version_id":"c4ff2e87-169f-4dc0-a328-9a0b4836c351"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"輸出入細動脈","subitem_subject_scheme":"Other"},{"subitem_subject":"腎硬化症","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"オートファジー","subitem_subject_scheme":"Other"},{"subitem_subject":"加齢","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"糸球体血行動態調節機構の加齢性変化：腎臓の老化における病態生理的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糸球体血行動態調節機構の加齢性変化：腎臓の老化における病態生理的意義"},{"subitem_title":"Aging-related alterations in the control of glomerular hemodynamics: pathophysiological significance in the aging kidney.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18873","relation_version_is_last":true,"title":["糸球体血行動態調節機構の加齢性変化：腎臓の老化における病態生理的意義"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:46:24.656726+00:00"}