{"created":"2023-06-20T16:47:13.992628+00:00","id":18872,"links":{},"metadata":{"_buckets":{"deposit":"9395849d-412f-432b-b1c7-6d671959665b"},"_deposit":{"created_by":3,"id":"18872","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18872"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018872","sets":["14:2667:4374"]},"author_link":["31958","31957","31956"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：当該研究により、定型抗精神病薬であるハロペリドールと非定型抗精神病薬であるリスペリドンでは、前頭葉におけるKv3.1およびKv3.2の発現量に異なった影響をもたらすことが判明した。すなわち、Kv3.1タンパクはハロペリドール、リスペリドンの長期投与を受けたラットの前頭葉においてともに発現量の増加をもたらすが、Kv3.2タンパクは同部位においてハロペリドールの投与によって増加する一方、リスペリドンの投与では減少を生じる。また、小脳においてもKv3.2タンパクは同様に変化したが、海馬や視床、線条体においては変化をみとめなかった。以上の結果を精神神経学会学術総会にて報告した。\n研究成果の概要（英文）：In this study, we found that haloperidol, a typical APD and risperidone, an atypical APD differentially modulated cortical Kv3.1 and Kv3.2 channels. While both haloperidol and risperidone significantly increased Kv3.1 protein levels in rat prefrontal cortex, Kv3.2 protein levels showed an increase and a decrease in the same region by haloperidol and risperidone, respectively. A similar pattern of Kv3.2 change was found in cerebellum, however, no significant changes were found in Kv3.2 protein levels in hippocampus, thalamus and striatum. These result were reported in Annual Meeting of the Japanese Society of Psychiatry and Neurology.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26461727;   研究分野：精神神経科学分野;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461727/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YANAGI, Masaya"},{"subitem_text_language":"en","subitem_text_value":"SHIRAKAWA, Osamu"},{"subitem_text_language":"en","subitem_text_value":"TAMMINGA CA"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"University of Texas Southwestern Medical Center・ Professor"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柳, 雅也"},{"creatorName":"ヤナギ, マサヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"白川, 治"},{"creatorName":"シラカワ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Carol, A. Tamminga"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26461727seika.pdf","filesize":[{"value":"105.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26461727seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18872/files/26461727seika.pdf"},"version_id":"03193507-4875-4cae-bc4c-21f6d4ad5c94"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗精神病薬","subitem_subject_scheme":"Other"},{"subitem_subject":"統合失調症","subitem_subject_scheme":"Other"},{"subitem_subject":"Kv3ファミリー","subitem_subject_scheme":"Other"},{"subitem_subject":"Kv3.1","subitem_subject_scheme":"Other"},{"subitem_subject":"Kv3.2","subitem_subject_scheme":"Other"},{"subitem_subject":"GAD65","subitem_subject_scheme":"Other"},{"subitem_subject":"GAD67","subitem_subject_scheme":"Other"},{"subitem_subject":"前頭葉","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗精神病薬の作用機序を探る；Kv３チャネルファミリーの発現調節","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗精神病薬の作用機序を探る；Kv３チャネルファミリーの発現調節"},{"subitem_title":"Searching for mechanism of antipsychotic action; modulation of Kv3 channel family","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18872","relation_version_is_last":true,"title":["抗精神病薬の作用機序を探る；Kv３チャネルファミリーの発現調節"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:46:26.620987+00:00"}