{"created":"2023-06-20T16:47:13.722477+00:00","id":18868,"links":{},"metadata":{"_buckets":{"deposit":"18c4a18d-830d-497b-bebd-f793ffd43c9f"},"_deposit":{"created_by":3,"id":"18868","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18868"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018868","sets":["14:2667:4374"]},"author_link":["31948","31947","31946"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：重症未熟児網膜症に対してranibizumab（0.25mg）を硝子体内投与し、その効果、再燃割合、血清中血管内皮増殖因子（VEGF）への影響を14例27眼で検討した。投与後2、3日以内に全例で網膜血管の拡張蛇行の改善、水晶体血管膜の退縮、増殖膜白鞘化が認められ、治療効果があったと判定された。7眼に治療後平均7.3週で再燃が認められた。投与前の血清VEGF濃度に比し、投与翌日のそれのみ有意に減少したが、投与１、２、４週後では有意差を認めず、ranibizumabの血清VEGF濃度抑制効果は一過性であると思われた。\n研究成果の概要（英文）：Intravitreal injection of ranibizumab (IVR) was performed in 27 eyes of 14 patients with severe retinopathy of prematurity (ROP). In each eyes, improvement of vascular dilatation and tortuosity, regression of tunica vasculosa lentis, and/or whitening of fibrovascular membranes was observed. Thus, IVR seemed to be effective in reducing disease activity in all eyes. However, reactivation was seen in 7 eyes at 7.3 weeks (mean) after IVR. Suppression of serum vascular endothelial growth factor was observed only at one day, but not 1, 2, and 4 weeks after IVR, compared with that of pre-IVR.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26462654;   研究分野：未熟児網膜症;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462654/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KUSAKA, Shunji"},{"subitem_text_language":"en","subitem_text_value":"KUNIYOSHI, Kazuki"},{"subitem_text_language":"en","subitem_text_value":"SUGIOKA, Koji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 教授"},{"subitem_text_value":"近畿大学医学部附属病院; 講師"},{"subitem_text_value":"近畿大学医学部附属病院; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"日下, 俊次"},{"creatorName":"クサカシュンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"國吉, 一樹"},{"creatorName":"クニヨシ, カズキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"杉岡, 孝二"},{"creatorName":"スギオカ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26462654seika.pdf","filesize":[{"value":"180.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26462654seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18868/files/26462654seika.pdf"},"version_id":"d8c0e510-67f1-4633-8869-7b5ab410cfb8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"未熟児網膜症","subitem_subject_scheme":"Other"},{"subitem_subject":"抗血管内皮増殖因子（VEGF）抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"Periostin","subitem_subject_scheme":"Other"},{"subitem_subject":"硝子体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"未熟児網膜症におけるperiostinの役割と2種の抗血管内皮増殖因子治療の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"未熟児網膜症におけるperiostinの役割と2種の抗血管内皮増殖因子治療の検討"},{"subitem_title":"The role of periostin in the pathogenesis of retinopathy of prematurity (ROP) and the effect of 2 anti-vascular endothelial growth factors in the treatment of ROP","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18868","relation_version_is_last":true,"title":["未熟児網膜症におけるperiostinの役割と2種の抗血管内皮増殖因子治療の検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:46:32.530840+00:00"}