{"created":"2023-06-20T16:47:13.585851+00:00","id":18866,"links":{},"metadata":{"_buckets":{"deposit":"da92af6c-3ba6-4a0e-af67-9b02084982de"},"_deposit":{"created_by":3,"id":"18866","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18866"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018866","sets":["14:2667:4374"]},"author_link":["31941"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：IgG4関連型自己免疫性膵炎の発症に関わる自然免疫反応について、解析を進めた。マウスの自己免疫性膵炎モデル及びヒトIgG4関連型自己免疫性膵炎の血液細胞・膵臓組織標本を用いて検討を行った。その結果、マウスの自己免疫性膵炎及びヒトIgG4関連型自己免疫性膵炎の双方において、形質細胞様樹状細胞(plasmacytoid dendritic cells, pDCs)の活性化が重要な役割を果たすことを見出した。pDCsは腸内細菌を認識することにより活性化され、IFN-alphaとIL-33を産生することにより、自己免疫性膵炎を誘導していることが明らかになった。\n研究成果の概要（英文）：We tried to elucidate innate immune responses involved in the development of IgG4-related autoimmune pancreatitis (AIP). To this end, we utilized samples obtained from murine experimental models of AIP and human IgG4-related AIP. In both human and animal studies, we found that AIP-related innate immune responses are characterized by activation of plasmacytoid dendritic cells (pDCs). The development of AIP depends upon both IFN-alpha and IL-33 produced by pDCs. Taken together, these data suggest that activation of pDCs upon sensing of intestinal microflora induces IgG4-related AIP through the production of IFN-alpha and IL-33. ","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：挑戦的萌芽研究;  研究期間：2015～2016;   課題番号：15K15370;   研究分野：消化器免疫学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15370/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"WATANABE, Tomohiro"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡邉, 智裕"},{"creatorName":"ワタナベ, トモヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"15K15370seika.pdf","filesize":[{"value":"92.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K15370seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18866/files/15K15370seika.pdf"},"version_id":"c14721ba-6cd5-4eea-a6f7-57e04eb3bbd5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IgG4関連疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫性膵炎","subitem_subject_scheme":"Other"},{"subitem_subject":"形質細胞様樹状細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腸内細菌叢からみたIgG4関連疾患の発症機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腸内細菌叢からみたIgG4関連疾患の発症機序の解明"},{"subitem_title":"Elucidation of immuno-pathogenesis of IgG4-related disease by focusing on innate immune responses to intestinal microflora","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18866","relation_version_is_last":true,"title":["腸内細菌叢からみたIgG4関連疾患の発症機序の解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:46:36.367222+00:00"}