{"created":"2023-06-20T16:47:13.315759+00:00","id":18862,"links":{},"metadata":{"_buckets":{"deposit":"fbfd9c56-a933-43f1-b254-abcf93cbdcfb"},"_deposit":{"created_by":3,"id":"18862","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18862"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018862","sets":["14:2667:4374"]},"author_link":["31933","31930","31931","31932"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：第3脳室を囲む視床下部は細分化された核の神経活動を介して全身の生理的恒常性維持と組織再生に関わる。継続的な運動を脳卒中発症ラットにさせると脳傷害後の神経再生に重要な側脳室下帯の神経新生・分化・成熟に加え、第3脳室神経幹細胞候補のtanycyteの自己複製と神経新生・成熟の活性化を認めた。また脳室域のFGF-2とEGF産生が増加した。脳組織再生には傷害部の骨髄由来血管系幹細胞による血管網の構築が重要である。骨髄幹細胞は骨髄の間葉系細胞と血管内皮細胞やSDF-1などにより維持されるが、脳血管障害時にはこれらの細胞極性と増殖因子の産生が低下した。運動は幹細胞の微小環境を改善し脳傷害の改善に関与する。\n研究成果の概要（英文）：Beneficial effects of exercise (EX) in the hypothalamus and bone marrow (BM) were examined for homeostasis and regeneration. A neural progenitor cell, tanycytes, proliferated, differentiated, and matured to NeuN+ neuron in the hypothalamus of adult SHRSP. EX activated tanycytes and promoted cell turn over. Neurogenesis may require FGF-2 and EGF production in adult hypothalamus, and restore physiological and neural functions effectively after stroke in EX SHRSP. Myeloid cell ratio was increased with progression of cerebrovascular disease and that was normalized by EX. Stroke injury induced dynamic fluctuation in SDF-1 distribution that correlated with variations in niche occupation of CD34+/c-kit+ angiogenic stem/progenitor cells. Stem cell niches (SDF-1) in EX responded to injury-related cues that mobilized CD34+ cells from endosteal niche after stroke to sinusoidal vascular niche, which promoted the progenitor proliferation. EX improves the mobilization and activation of BM stem cells.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26350918;   研究分野：薬理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26350918/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NIWA, Atsuko"},{"subitem_text_language":"en","subitem_text_value":"TAKAHASHI, Hideo"},{"subitem_text_language":"en","subitem_text_value":"HAMASAKI, Shinichi"},{"subitem_text_language":"en","subitem_text_value":"KOBORI, Takuro"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部付属病院; 助教"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丹羽, 淳子"},{"creatorName":"ニワ, アツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"髙橋, 英夫"},{"creatorName":"タカハシ, ヒデオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"濱﨑, 真一"},{"creatorName":"ハマサキ, シンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小堀, 宅郎"},{"creatorName":"コボリ, タクロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26350918seika.pdf","filesize":[{"value":"487.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26350918seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18862/files/26350918seika.pdf"},"version_id":"213687cf-df5a-4ba2-a737-56426799a3fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脳血管障害","subitem_subject_scheme":"Other"},{"subitem_subject":"運動","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮前駆細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"神経新生","subitem_subject_scheme":"Other"},{"subitem_subject":"第3脳室（視床下部）","subitem_subject_scheme":"Other"},{"subitem_subject":"骨髄","subitem_subject_scheme":"Other"},{"subitem_subject":"微小環境（ニッチ）","subitem_subject_scheme":"Other"},{"subitem_subject":"恒常性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"運動習慣による傷害脳再生起点の延長","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"運動習慣による傷害脳再生起点の延長"},{"subitem_title":"Exercise promotes homeostatic control and post-injury regeneration by altering stem cell niche","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18862","relation_version_is_last":true,"title":["運動習慣による傷害脳再生起点の延長"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:46:44.015242+00:00"}